Changes in plasma levels of adhesion molecules after percutaneous mitral balloon valvuloplasty

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dc.authoridmemişoğlu, funda/0000-0003-3905-1182;
dc.authorwosidmemişoğlu, funda/AAA-4392-2021
dc.authorwosidIleri, Mehmet/A-6525-2018
dc.contributor.authorYetkin, E
dc.contributor.authorErbay, AR
dc.contributor.authorTurhan, H
dc.contributor.authorBalci, M
dc.contributor.authorYetkin, F
dc.contributor.authorYetkin, G
dc.contributor.authorIleri, M
dc.date.accessioned2024-08-04T20:13:41Z
dc.date.available2024-08-04T20:13:41Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Adhesion molecules are expressed on vascular endothelium and on immune and inflammatory cells. Recently increased levels of adhesion molecules have been shown in patients with rheumatic mitral stenosis. This study examined the serum levels of the adhesion molecules intercellular adhesion molecule I (ICAM-1), vascular cell adhesion molecule I (VCAM-1), and E-selectin in patients with rheumatic mitral stenosis and the effects of percutaneous mitral balloon valvuloplasty (PMBV) on these adhesion molecules. Materials and methods: Thirty five patients (3 men, 32 women, mean age 39 5 years) with severe rheumatic mitral stenosis who underwent percutaneous balloon mitral valvuloplasty, and 35 age and sex matched healthy control subjects were included in the study. Serum levels of ICAM-1, VCAM-I, and E-selectin were measured in all patients who underwent PMBV and in all control subjects. Blood samples were taken for measurement of adhesion molecules immediately before and 24 h after the mitral balloon valvuloplasty. Results: The plasma levels of soluble adhesion molecules E-selectin, ICAM-I and VCAM-I were significantly elevated in patients with mitral stenosis compared to control subjects: E-selectin, 97 +/- 59 vs. 45 +/- 24 ng/ml (P=.001), sICAM-1, 874 +/- 301 ng/ml vs. 238 82 ng/ml (P<.0001); sVCAM-1, 3056 +/- 763 ng/ml vs. 985 +/- 298 ng/ml (P<.0001). Plasma levels of VCAM-1 significantly increased 24 h after the valvuloplasty procedure (3056 +/- 763 ng/ml vs. 3570 +/- 1225 ng/ml P=.013). Plasma levels of E-selectin showed a significant decrease after PMBV (97 +/- 59 vs. 70 +/- 58 ng/ml, P=.043) and plasma levels of ICAM-I did not show any change after PMBV (874 +/- 301 vs. 944 +/- 3 77 ng/ml, P=.356). Conclusion: Cellular adhesion molecules, sICAM-1, E-selectin, sVCAM-1 have shown changes in different directions in response to PMBV These results necessitate further studies to clarify the mechanism underlying the association between adhesion molecules and PMBV as well as rheumatic mitral stenosis. (C) 2004 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/s1054-8807(03)00128-5
dc.identifier.endpage108en_US
dc.identifier.issn1054-8807
dc.identifier.issue2en_US
dc.identifier.pmid15033160en_US
dc.identifier.scopus2-s2.0-12144286407en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage103en_US
dc.identifier.urihttps://doi.org/10.1016/s1054-8807(03)00128-5
dc.identifier.urihttps://hdl.handle.net/11616/93785
dc.identifier.volume13en_US
dc.identifier.wosWOS:000220483600007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofCardiovascular Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadhesion moleculesen_US
dc.subjectmitral stenosisen_US
dc.subjectpercutaneous mitral balloon valvuloplastyen_US
dc.titleChanges in plasma levels of adhesion molecules after percutaneous mitral balloon valvuloplastyen_US
dc.typeArticleen_US

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