Elevated cardiac oxidative stress in newborn rats from mothers treated with atosiban

Basit Öğe Kaydı
dc.authoridKaraer, Abdullah/0000-0002-2010-6211
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridBilgic, Sedat/0000-0001-8410-2685
dc.authorwosidKaraer, Abdullah/ABI-4667-2020
dc.authorwosidÖZEROL, ELİF/AAA-6707-2021
dc.authorwosidBİLGİÇ, Sedat/AEM-2044-2022
dc.authorwosidSimsek, Yavuz/AAH-9894-2021
dc.authorwosidbilgiç, sedat/JVN-5459-2024
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.contributor.authorSimsek, Yavuz
dc.contributor.authorCelik, Onder
dc.contributor.authorKaraer, Abdullah
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorGul, Mehmet
dc.contributor.authorOzerol, Elif
dc.contributor.authorBilgic, Sedat
dc.date.accessioned2024-08-04T20:36:00Z
dc.date.available2024-08-04T20:36:00Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe purpose of this study was to evaluate the cardiac and cerebral oxidative stress in the offspings of pregnant rats treated with oxytocin antagonist atosiban. Experimentally naive, adult female Wistar-albino rats (200-250 g) were mated with adult male rats for copulation. After confirming pregnancy, eight gravid rats were then randomly assigned into two equal groups. The animals were treated from days 15 to 20 of gestation. One group acted as a control group, and received intraperitoneal (i.p.) injections of saline in a daily dose volume of 6 mg/kg/day. The second group received 6 mg/kg/day i.p. atosiban. On day 21 of gestation, pups were delivered by cesarean. The heart and brain tissues of the newborn rats were dissected and sent for the measurement of total oxidant status, total antioxitant status and oxidative stress index. There was no significant difference in birthweight or in the number of pups between two groups. Newborns from atosiban-treated mothers showed significantly increased oxidative stress in the plasma and heart tissue than that of controls which was confirmed by histological examination (P < 0.05). Oxidative stress parameters and histopathological results of the brain tissues of newborns were similar between two groups (P > 0.05). Oxytocin receptor blockage for the treatment of premature delivery may be associated with increased fetal morbidity and mortality secondary to the elevated oxidative stress in the heart of the newborns.en_US
dc.identifier.doi10.1007/s00404-011-2069-5
dc.identifier.endpage661en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue3en_US
dc.identifier.pmid21866331en_US
dc.identifier.scopus2-s2.0-84863205335en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage655en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-011-2069-5
dc.identifier.urihttps://hdl.handle.net/11616/95705
dc.identifier.volume285en_US
dc.identifier.wosWOS:000300246100015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives of Gynecology and Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObstetric laboren_US
dc.subjectPrematureen_US
dc.subjectAtosibanen_US
dc.subjectOxidative stressen_US
dc.subjectOxytocinen_US
dc.titleElevated cardiac oxidative stress in newborn rats from mothers treated with atosibanen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu