Circulating Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels Are Associated With Erectile Dysfunction in Patients Without Known Coronary Artery Disease

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dc.authoridFirdolas, Fatih/0000-0003-2097-9853
dc.authoridÇELİK, AHMET/0000-0002-9417-7610;
dc.authorwosidcelik, Ahmet/IAP-5710-2023
dc.authorwosidFirdolas, Fatih/W-7682-2018
dc.authorwosidÇELİK, AHMET/AAA-6615-2021
dc.authorwosidBentli, Recep/AAB-4140-2021
dc.contributor.authorKobat, Mehmet Ali
dc.contributor.authorFirdolas, Fatih
dc.contributor.authorBalin, Mehmet
dc.contributor.authorCelik, Ahmet
dc.contributor.authorBentli, Recep
dc.contributor.authorBaydas, Adil
dc.date.accessioned2024-08-04T20:37:54Z
dc.date.available2024-08-04T20:37:54Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim. Endothelial dysfunction and microvascular damage are involved in the pathogenesis of erectile dysfunction (ED). Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) is identified endothelial receptor for oxidized low-density lipoprotein (ox-LDL) that plays a pivotal role in ox-LDL-induced endothelial dysfunction. The purpose of the current study was to determine the association between sLOX-1 and ED in patients without known coronary artery disease (CAD). Main Outcome Measures. Diagnosis of ED was based on the International Index of Erectile Function Score-5. Levels of sLOX-1 were measured in serum by enzyme-linked immunosorbent assay. Methods. One hundred thirty-eight subjects with ED patients without known CAD (ED group) and 75 age-matched subjects without ED and known CAD (Non-ED Group) were included in this study. Results. Plasma levels of sLOX-1 were significantly higher in ED than in Non-ED group (9587 and 49 +/- 30pg/mL, respectively, P<0.001). The levels of sLOX-1 highly negative correlated with score of ED (r=-0.618, P<0.001). The sLOX-1 levels >75pg/mL predicts ED with 26.8% sensitivity and 96.0% specificity on receiver operator characteristic analysis. Conclusions. Our study demonstrated that serum sLOX-1 levels were associated with endothelial dysfunction that predicts ED. Moreover, the current study revealed that there was strong negative correlation between the levels of circulating sLOX-1 and score of ED. This study suggested sLOX-1 may be involved in the pathogenesis of ED in patients without known CAD. Kobat MA, Frdolas F, Balin M, Celik A, Bentli R, and Baydas A. Circulating soluble lectin-like oxidized low-density lipoprotein receptor-1 levels are associated with erectile dysfunction in patients without known coronary artery disease. J Sex Med 2013;10:2782-2789.en_US
dc.identifier.doi10.1111/j.1743-6109.2012.02964.x
dc.identifier.endpage2789en_US
dc.identifier.issn1743-6095
dc.identifier.issn1743-6109
dc.identifier.issue11en_US
dc.identifier.pmid23088332en_US
dc.identifier.scopus2-s2.0-84887079108en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2782en_US
dc.identifier.urihttps://doi.org/10.1111/j.1743-6109.2012.02964.x
dc.identifier.urihttps://hdl.handle.net/11616/96263
dc.identifier.volume10en_US
dc.identifier.wosWOS:000326465900018en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofJournal of Sexual Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndothelial Functionen_US
dc.subjectErectile Dysfunctionen_US
dc.subjectMicrovascular Damageen_US
dc.subjectSoluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1en_US
dc.titleCirculating Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels Are Associated With Erectile Dysfunction in Patients Without Known Coronary Artery Diseaseen_US
dc.typeArticleen_US

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