Preventive Effects of Melatonin Against Post-Traumatic Contusional Expansion in Rats

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dc.contributor.authorAladag, Mehmet Arif
dc.contributor.authorGolcek, Cengiz
dc.contributor.authorPasahan, Ramazan
dc.contributor.authorGozukara, Harika
dc.date.accessioned2026-04-04T13:30:45Z
dc.date.available2026-04-04T13:30:45Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractAIM: To provide insight into the molecular mechanism of contusional expansion (CE) by creating experimentally induced contusion cerebri (CC) in rats and investigating whether melatonin administration prevents CE or not. MATERIAL and METHODS: Rats were randomized into four groups: Group 1 (control, n=5), group 2 (trauma, n=25), group 3 (trauma plus placebo, n=25), and, group 4 (trauma plus melatonin, n=25). Rats in the control group were sacrificed without undergoing any invasive procedure. Groups 2, 3, and 4 were further divided into 5 subgroups (A-E), with animals in each sacrificed at 12, 24, 72, 120, and 168 h after CC induction. Samples from these subgroups were analyzed for levels of caspase 3, caspase 8, and matrix metalloproteinase-9, as well as for evidence of ischemia, blood-brain barrier (BBB) breakdown, vasogenic edema (VE), and hemorrhage. Temporal progression of CE and correlations between these variables were also investigated. RESULTS: Our results indicated that the ischemia, BBB breakdown, and VE are early events that initiate CE, with VE and hemorrhagic transformation due to BBB breakdown identified as key factors. Melatonin treatment prevented CE injury. CONCLUSION: Melatonin, a safe and well-tolerated substance with minimal toxicity, may serve as a potential therapeutic agent for preventing CE injury.
dc.description.sponsorshipScientific Research Projects Unit of Inonu University [:2015/81]
dc.description.sponsorshipFunding: This study received financial support from The Scientific Research Projects Unit of Inonu University for financial support. (grant no:2015/81) The authors thank to Nusret Akpolat for his support in histopathological preparations and analysis, and to Hakan Parlakpinar for his support in the preparation of the article.
dc.identifier.doi10.5137/1019-5149.JTN.48436-25.3
dc.identifier.endpage24
dc.identifier.issn1019-5149
dc.identifier.issue1
dc.identifier.pmid41553211
dc.identifier.scopus2-s2.0-105029271843
dc.identifier.scopusqualityQ3
dc.identifier.startpage16
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.48436-25.3
dc.identifier.urihttps://hdl.handle.net/11616/108360
dc.identifier.volume36
dc.identifier.wosWOS:001683828400004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neurosurgical Soc
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectMelatonin
dc.subjectBlood-brain barrier
dc.subjectContusional expansion
dc.subjectMatrix metalloproteinase-9
dc.subjectCaspases
dc.titlePreventive Effects of Melatonin Against Post-Traumatic Contusional Expansion in Rats
dc.typeArticle

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