A novel schiff base derivative for effective treatment of azoxymethane induced colon cancer
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Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
IJPSR
Access Rights
info:eu-repo/semantics/openAccess
Abstract
The field of cancer research has been emerged in recent years for the
development of specific drugs to cancer treatment. New agents with the ability to provide
efficient treatment by reducing side effects has led to new opportunities for improving
agents for cytotoxic therapies. While there are several drugs for colon cancer treatment,
researchers are trying to evaluate new agents or combinations of existing ones which can
be used efficiently. Schiff bases with a wide range of variety and biological properties
including anticancer activity might be used for colon cancer treatment. In the current
study, a novel schiff base derivative synthesized by our group was tested in vivo for
colon cancer. In a model of azoxymethane (AOM) induced colorectal cancer,
chemopreventive properties of schiff base was also analyzed in rats. While AOM induced
de novo crypt formation, adenocarcinoma and dysplasia development, schiff base
application reduced the number of aberrant crypt foci (ACF), dysplasia or
adenocarcinoma. Analysis of the intestinal mucosa showed that peritoneal administration
of SB complex not only decreased the protein expression of COX-2, Bcl-2 and NF-κB
but also enhanced the Bax expression suggesting the apoptotic and anti-proliferative
effects for this compound. Our findings showed that SB complex might be used for the
colorectal cancer treatment. Further studies are highly warranted to obtain additional
insights and identify mode of action for the schiff base.
Description
Keywords
Schiff base, Colon cancer, Azoxymethane, Aberrant crypt foci
Journal or Series
IJPSR
WoS Q Value
Scopus Q Value
Volume
5
Issue
8
Citation
Doğan, A. Başak, N. Demirci, S. Telci, D. Dede, B. Tuzcu, M. Özercan, İ. H. Şahin, K. Şahin, F. (2014). A Novel Schiff Base Derivative For Effective Treatment of Azoxymethane induced colon cancer . IJPSR, 5(8): 3544-3550.
