Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus: A multicenter study

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dc.authoridYUKSEL, SELCUK/0000-0001-9415-1640
dc.authoridYıldız, Mehmet/0000-0001-8528-2163
dc.authoridKisla Ekinci, Rabia Miray/0000-0001-6234-822X
dc.authoridKISAOGLU, Hakan/0000-0002-1095-3222
dc.authoridAYTAC, Gulcin/0000-0003-3821-5288
dc.authoridBarut, Kenan/0000-0001-8459-2872
dc.authoridPaç Kısaarslan, Ayşenur/0000-0002-1800-9922
dc.authorwosidYUKSEL, SELCUK/C-5473-2015
dc.authorwosidYıldız, Mehmet/GPP-1539-2022
dc.authorwosidELMAS, Ahmet Taner/W-4101-2017
dc.authorwosidKisla Ekinci, Rabia Miray/S-8411-2018
dc.authorwosidKISAOGLU, Hakan/GVT-0229-2022
dc.authorwosidKALYONCU, Mukaddes/AAM-2913-2021
dc.authorwosidAYTAC, Gulcin/IYS-5897-2023
dc.contributor.authorKisaarslan, Aysenur Pac
dc.contributor.authorCicek, Sumeyra Ozdemir
dc.contributor.authorBatu, Ezgi D.
dc.contributor.authorSahin, Sezgin
dc.contributor.authorGurgoze, Metin K.
dc.contributor.authorCetinkaya, Sibel Balci
dc.contributor.authorEkinci, Miray Kisla
dc.date.accessioned2024-08-04T20:53:32Z
dc.date.available2024-08-04T20:53:32Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Neuropsychiatric (NP) involvement is a restricted area in juvenile-onset systemic lupus erythematosus (jSLE). Aim: To investigate the prevalence, demographic and clinical features, and outcomes of the neurological involvement in the Turkish jSLE population. Methods: This study was based upon 24 referral centers' SLE cohorts, multicenter and multidisciplinary network in Turkey. Patient data were collected by a case report form which was standardized for NP definitions according to American Collage of Rheumatology (ACR). Systemic Lupus International Collab-orating Clinics/American College of Rheumatology Damage Index (SDI) neuropsychiatric part was used to determine NP damage. Variables were evaluated Ward's hierarchical clustering analyses, univariate, and multivariate logistic regression analyses. Results: A hundred forty-nine of 1107 jSLE patients had NP involvement (13.5%). The most common NPSLE findings were headache (50.3%), seizure (38.3%), and acute confusional state (33.6%). Five clusters were identified with all clinical and laboratory findings. The first two clusters involved neuropathies, demyelinating diseases, aseptic meningitis, and movement disorder. Cluster 3 involved headache, activ-ity markers and other SLE involvements. Idiopathic intracranial hypertension, cerebrovascular disease, cognitive dysfunction, psychiatric disorders and SLE antibodies were in the fourth, and acute confusional state was in the fifth cluster. In multivariate analysis, APA positivity; OR: 2.820, (%95CI: 1.002-7.939), P: 0,050, plasmapheresis; OR: 13.804 (%95CI: 2.785-68.432), P: 0,001, SLEDAI scores; OR: 1.115 (%95CI: (1.049-1.186), P: 0,001 were associated with increased risk for neurologic sequelae. Conclusion: We detected the prevalence of juvenile NPSLE manifestations in Turkey. We have identified five clusters that may shed light pathogenesis, treatment and prognosis of NP involvements. We also determined risk factors of neurological sequelae. Our study showed that new definitions NP involvements and sequelae for childhood period are needed. (c) 2023 Socie ' te ' franc,aise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.jbspin.2023.105559
dc.identifier.issn1297-319X
dc.identifier.issn1778-7254
dc.identifier.issue4en_US
dc.identifier.pmid36858168en_US
dc.identifier.scopus2-s2.0-85150809280en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.jbspin.2023.105559
dc.identifier.urihttps://hdl.handle.net/11616/101244
dc.identifier.volume90en_US
dc.identifier.wosWOS:000963446200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofJoint Bone Spineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClusteren_US
dc.subjectJuvenileen_US
dc.subjectSystemic lupus erythematosusen_US
dc.subjectNeurologic manifestationsen_US
dc.titleNeuropsychiatric involvement in juvenile-onset systemic lupus erythematosus: A multicenter studyen_US
dc.typeArticleen_US

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