Elevated Monocyte to High-Density Lipoprotein Cholesterol Ratio and Endothelial Dysfunction in Behcet Disease

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dc.authoridCansel, Mehmet/0000-0003-4740-4371
dc.authoridAkaycan, Jülide/0000-0002-9174-6777;
dc.authorwosidCansel, Mehmet/ABI-6324-2020
dc.authorwosidErmis, Necip/HJP-7061-2023
dc.authorwosidAkaycan, Jülide/ABI-2397-2020
dc.authorwosidErmis, Necip/A-5184-2018
dc.contributor.authorAcikgoz, Nusret
dc.contributor.authorKurtoglu, Ertugrul
dc.contributor.authorYagmur, Julide
dc.contributor.authorKapicioglu, Yelda
dc.contributor.authorCansel, Mehmet
dc.contributor.authorErmis, Necip
dc.date.accessioned2024-08-04T20:44:20Z
dc.date.available2024-08-04T20:44:20Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBehcet disease (BD) is a multisystemic disorder characterized by endothelial dysfunction and inflammation. Monocyte to high-density lipoprotein cholesterol ratio (MHR) is a recently emerged indicator of inflammation and oxidative stress. Sixty patients with BD and 50 control individuals were included to investigate the relationship between MHR and endothelial dysfunction. Endothelial function was assessed by flow- and nitroglycerin-mediated dilatation technique (FMD and NMD, respectively). Serum high-sensitivity C-reactive protein (hsCRP) levels were measured in all study participants. The MHR and hsCRP levels were significantly higher in patients with active BD than in controls. Brachial artery FMD was significantly lower in patients with active BD than in controls. Brachial artery NMD was similar between groups. There was a strong inverse correlation between MHR and FMD and a strong positive correlation between MHR and serum hsCRP levels. Thus, elevated MHR may be a useful marker reflecting impaired endothelial function and systemic inflammation in patients with BD.en_US
dc.identifier.doi10.1177/0003319717704748
dc.identifier.endpage70en_US
dc.identifier.issn0003-3197
dc.identifier.issn1940-1574
dc.identifier.issue1en_US
dc.identifier.pmid28421814en_US
dc.identifier.scopus2-s2.0-85043335967en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage65en_US
dc.identifier.urihttps://doi.org/10.1177/0003319717704748
dc.identifier.urihttps://hdl.handle.net/11616/98186
dc.identifier.volume69en_US
dc.identifier.wosWOS:000417677800011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofAngiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbiomarkersen_US
dc.subjectendothelial dysfunctionen_US
dc.subjectflow-mediated dilationen_US
dc.subjectC-reactive proteinen_US
dc.subjectinflammationen_US
dc.titleElevated Monocyte to High-Density Lipoprotein Cholesterol Ratio and Endothelial Dysfunction in Behcet Diseaseen_US
dc.typeArticleen_US

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