The association between vitamin D receptor polymorphisms and multiple sclerosis in a Turkish population

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dc.authoridKamisli, Ozden/0000-0003-1114-7860
dc.authoridAcar, Ceren/0000-0003-1842-9203
dc.authoridKamisli, Ozden/0000-0003-1114-7860
dc.authoridSözen, Mustafa Mert/0000-0002-1672-2206
dc.authoridVaizoğlu, Dilara/0000-0003-4584-0954
dc.authoridozcan, abdulcemal/0000-0002-6759-7556
dc.authoridTecellioglu, Mehmet/0000-0002-8381-9630
dc.authorwosidAcar, Ceren/B-5758-2008
dc.authorwosidKamisli, Ozden/JVZ-0145-2024
dc.authorwosidAcar, Ceren/M-2926-2019
dc.authorwosidKamisli, Ozden/AAA-6553-2020
dc.authorwosidSözen, Mustafa Mert/E-7278-2011
dc.authorwosidVaizoğlu, Dilara/JEF-9241-2023
dc.authorwosidozcan, abdulcemal/B-1348-2008
dc.contributor.authorKamisli, Ozden
dc.contributor.authorAcar, Ceren
dc.contributor.authorSozen, Mert
dc.contributor.authorTecellioglu, Mehmet
dc.contributor.authorYucel, Fatma Ebru
dc.contributor.authorVaizoglu, Dilara
dc.contributor.authorOzcan, Cemal
dc.date.accessioned2024-08-04T20:44:15Z
dc.date.available2024-08-04T20:44:15Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Multiple sclerosis (MS) is a chronic, demyelinating disease of the central nervous system (CNS). Genetic and environmental factors are important in disease development. Many studies have investigated the relationship between MS and VDR polymorphisms. VDR gene polymorphism has not been previously studied in Turkish MS patients. We aimed to investigate the relationship between MS and VDR genotypes Taq I, Apa I and Fok I polymorphisms in a Turkish population. Methods: 167 MS patients and 146 healthy control subjects were included in the present study. MS and the VDR TaqI (rs731236), ApaI (rs7975232), and FokI (rs2228570) polymorphisms were investigated. Results: The study enrolled 167 patients (121 females, 46 males) with MS and 146 healthy individuals (88 females, 58 males). The frequency of only the Fok I polymorphism differed significantly between the two groups (p = 0.002). The TaqI (rs731236) and ApaI (rs7975232) genotype distributions were not significantly different between MS patients and healthy controls (p = 0.626 and p = 0.990, respectively). Also there were no significant gender difference between patients and controls for Taq I and Apa I. Conclusion: In conclusion, we found a significant association between MS and the FokI polymorphism in our region of Turkey. However, the results may be different in other populations. More epidemiological and genetic studies are needed to explain the association between genetic factors and MS.en_US
dc.description.sponsorshipInonu University Scientific Research Unit [2015/99]en_US
dc.description.sponsorshipThis study was supported by Inonu University Scientific Research Unit Grant Number: 2015/99 (BAP# 2015/99).en_US
dc.identifier.doi10.1016/j.msard.2018.01.002
dc.identifier.endpage81en_US
dc.identifier.issn2211-0348
dc.identifier.issn2211-0356
dc.identifier.pmid29331875en_US
dc.identifier.scopus2-s2.0-85040232064en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage78en_US
dc.identifier.urihttps://doi.org/10.1016/j.msard.2018.01.002
dc.identifier.urihttps://hdl.handle.net/11616/98108
dc.identifier.volume20en_US
dc.identifier.wosWOS:000428031100019en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofMultiple Sclerosis and Related Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultiple sclerosisen_US
dc.subjectVitamin Den_US
dc.subjectVitamin D receptoren_US
dc.subjectPolymorphismen_US
dc.titleThe association between vitamin D receptor polymorphisms and multiple sclerosis in a Turkish populationen_US
dc.typeArticleen_US

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