Clinical Characteristics and Outcomes of COVID-19 Patients with Overweight and Obesity: Turkish Nationwide Cohort Study (TurCObesity)

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dc.authoridDemirci, Ibrahim/0000-0003-0498-3115
dc.authoridDagdelen, Selcuk/0000-0002-0513-1750
dc.authoridSonmez, Alper/0000-0002-9309-7715
dc.authoridsahin, mustafa/0000-0002-4718-0083
dc.authoridSatman, Ilhan/0000-0001-8613-1797
dc.authoridTASCI, ILKER/0000-0002-0936-2476
dc.authoridUnluturk, Ugur/0000-0002-5054-1396
dc.authorwosidDemirci, Ibrahim/AAR-3277-2020
dc.authorwosidCaglayan, Murat/AGY-9057-2022
dc.authorwosidDagdelen, Selcuk/A-9432-2017
dc.authorwosidCelik, Osman/KLZ-6766-2024
dc.authorwosidSonmez, Alper/H-8588-2019
dc.authorwosidsahin, mustafa/AAH-3394-2019
dc.authorwosidSatman, Ilhan/AAS-7044-2020
dc.contributor.authorSahin, Ibrahim
dc.contributor.authorHaymana, Cem
dc.contributor.authorDemir, Tevfik
dc.contributor.authorDemirci, Ibrahim
dc.contributor.authorTasci, Ilker
dc.contributor.authorAtmaca, Aysegul
dc.contributor.authorCakal, Erman
dc.date.accessioned2024-08-04T20:50:34Z
dc.date.available2024-08-04T20:50:34Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose While obesity is related to more severe outcomes of coronavirus disease 2019 (COVID-19), factors leading to poor prognosis still remain unclear. The present study evaluated the outcomes of COVID-19 patients who were overweight or obese and variables associated with severe disease in a large group of consecutive cases. Methods A nationwide retrospective cohort study was performed using the Turkish National Healthcare Database. Demographic characteristics, laboratory tests, comorbidities, and medications of patients registered between March 11 and May 30, 2020, were recorded. Results A total of 14,625 patients (median age:42, IQR:26 years; female 57.4%) with normal weight (34.7%), overweight (35.6%), and obesity (29.7%) were included. Hospitalization, ICU admission, intubation/mechanical ventilation, pulmonary involvement, and mortality were significantly higher in patients who were overweight or obese. In adjusted analyses, both overweight (OR, 95% CI: 1.82, 1.04-3.21; p=0.037) and obesity (OR, 95% CI: 2.69, 1.02-1.05; p<0.001) were associated with a higher intubation/mechanical ventilation rate but only obesity was associated with increased mortality (OR, 95% CI: 2.56, 1.40-4.67; p=0.002). Old age, male gender, chronic kidney disease, and high C reactive protein levels were independently associated with COVID-19 mortality in overweight or obese patients. Conclusions COVID-19 patients who were overweight or obese were more likely to have adverse outcomes but only obesity was a predictor of mortality. Such patients should receive urgent medical attention and active management, especially the elderly, men, and people with chronic kidney disease.en_US
dc.identifier.doi10.1055/a-1552-4449
dc.identifier.endpage124en_US
dc.identifier.issn0947-7349
dc.identifier.issn1439-3646
dc.identifier.issue2en_US
dc.identifier.pmid34384122en_US
dc.identifier.scopus2-s2.0-85113155584en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage115en_US
dc.identifier.urihttps://doi.org/10.1055/a-1552-4449
dc.identifier.urihttps://hdl.handle.net/11616/100149
dc.identifier.volume130en_US
dc.identifier.wosWOS:000685230700002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofExperimental and Clinical Endocrinology & Diabetesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObesityen_US
dc.subjectoverweighten_US
dc.subjectCOVID-19en_US
dc.subjectmorbidityen_US
dc.subjectmortalityen_US
dc.titleClinical Characteristics and Outcomes of COVID-19 Patients with Overweight and Obesity: Turkish Nationwide Cohort Study (TurCObesity)en_US
dc.typeArticleen_US

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