The effects of acetylsalicylic acid, interferon-?, and vitamin E on prevention of parenteral nutrition-associate cholestasis

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dc.authoridMutus, Huseyin Murat/0000-0002-0059-1336
dc.authoridUĞURALP, SEMA/0000-0002-7628-0550
dc.authoridDemircan, Mehmet/0000-0002-4022-1276
dc.authorwosidMutus, Huseyin Murat/AAA-2357-2020
dc.authorwosidDemircan, Mehmet/AAW-7162-2020
dc.authorwosidUĞURALP, SEMA/ABH-6309-2020
dc.authorwosidGurer, Inanc Elif/C-3042-2016
dc.authorwosidDemircan, Mehmet/B-1904-2008
dc.contributor.authorDemircan, M
dc.contributor.authorUguralp, S
dc.contributor.authorMutus, M
dc.contributor.authorGurer, EI
dc.contributor.authorAtik, E
dc.contributor.authorTurhan, F
dc.contributor.authorGursoy, MH
dc.date.accessioned2024-08-04T20:12:02Z
dc.date.available2024-08-04T20:12:02Z
dc.date.issued1999
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Cholestasis is one of the major complications of parenteral nutrition. The purpose of this experimental study was to detect the effects of acetylsalicylic acid (ASA), vitamin E (Vit E), and interferon-alpha (IFN-alpha) on prevention of parenteral nutrition-associated cholestasis. Methods: Ten experimental groups, each consisting of 10 4-week-old Wistar albino rats, were formed: control 10- and 20-day groups (C-10 and C-20), parenteral nutrition-only 10- and 20-day groups (T-10 and T-20), ASA-supplemented parenteral nutrition 10- and 20-day groups (TA(10) and TA(20)), Vit E-supplemented parenteral nutrition 10- and 20-day groups (TE10 and TE20), and IFN-alpha-supplemented 10- and 20-day groups (TF10 and TF20). Acetylsalicylic acid, Vit E, and IFN-alpha were administered in the parenteral nutrition solution through an intraperitoneal route. At the end of the study, serum total bile acids, serum aspartate and alanine aminotransferases, and alkaline phosphatase were measured biochemically. In addition, the histopathologic findings of cholestasis were evaluated by using a morphologic portal inflammation index. Results: Although the difference in the serum levels of transferases and alkaline phosphatase was not significant among all groups (p > 0.05), it was significant in total bile acid levels (p 0.05). There was also a significant correlation between the histopathologic changes of the liver and serum total bile acid concentrations (p < 0.05). Portal inflammation in varying degrees was seen in all experimental groups, but not in the control groups. Serum total bile acid concentrations in parenteral nutrition groups receiving ASA were significantly lower than those in the parenteral nutrition-only group (p < 0.01). Although Vit E-supplemented parenteral nutrition was effective in preventing the development of cholestasis in the 10-day group (p < 0.05), it was not effective in the 20-day group when compared with incidence of cholestasis in the parenteral nutrition-only group (p > 0.05). Conversely, IFN-alpha-supplemented parenteral nutrition had no effect on cholestasis in the 10-day group (p > 0.05) but lowered cholestasis in the 20-day group when compared with incidence the parenteral nutrition-only group (p < 0.05). Conclusion: Our results indicate that acetylsalicylic acid may be beneficial in preventing, and alpha-interferon in treating, parenteral nutrition-associated cholestasis.en_US
dc.identifier.doi10.1097/00005176-199903000-00014
dc.identifier.endpage295en_US
dc.identifier.issn0277-2116
dc.identifier.issue3en_US
dc.identifier.pmid10067730en_US
dc.identifier.scopus2-s2.0-0032975097en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage291en_US
dc.identifier.urihttps://doi.org/10.1097/00005176-199903000-00014
dc.identifier.urihttps://hdl.handle.net/11616/93172
dc.identifier.volume28en_US
dc.identifier.wosWOS:000079227000014en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectacetylsalicylic aciden_US
dc.subjectcholestasisen_US
dc.subjectinterferon-alphaen_US
dc.subjectportal inflammationen_US
dc.subjecttotal parenteral nutritionen_US
dc.subjectvitamin Een_US
dc.titleThe effects of acetylsalicylic acid, interferon-?, and vitamin E on prevention of parenteral nutrition-associate cholestasisen_US
dc.typeArticleen_US

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