Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats

Basit Öğe Kaydı
dc.contributor.authorEşrefoğlu, Mukaddes
dc.contributor.authorAkıncı, Ayşin
dc.contributor.authorElbe, Hülya
dc.contributor.authorTaşlıdere, Elif
dc.contributor.authorTaşlıdere, Elif
dc.contributor.authorÇetin, Aslı
dc.contributor.authorAteş, Burhan
dc.date.accessioned2020-10-21T11:47:57Z
dc.date.available2020-10-21T11:47:57Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAbstract: In the present study, we tried to investigate the effects of melatonin, a novel antioxidant and a potent free radical scavenger, in stress-induced cerebral, cerebellar, cardiac, and hepatic oxidative damage using microscopic and biochemical analysis. A total of 32 male Wistar albino rats were divided into control, stress, stress + saline, and stress + melatonin groups. The rats from the stress groups were exposed to high stress conditions of starvation, immobilization, and cold exposure. The rats from the stress + melatonin group received melatonin daily at 20 mg/kg body weight intraperitoneally for 7 days. At the end of the experiment, the brain, cerebellum, heart, and liver were rapidly removed. The main histopathological damage scores (MHDSs) of the stress and stress + saline groups were higher than those of control group for all of the organs. The MHDSs of melatonin-administered group were lower than those of stress and stress + saline groups. The main tissue superoxide dismutase activities of the stress + melatonin group were even higher than those of the control group in the cerebellum and liver, and main tissue catalase activities of the stress + melatonin group were even higher than those of control group in all of the organs. As a conclusion, we found melatonin very effective in reducing stress-induced organ damage by inhibiting lipid peroxidation and supporting the cellular antioxidant defense system.en_US
dc.identifier.citationEŞREFOĞLU M,AKINCI A,ELBE H,TAŞLIDERE E,ÇETİN A,ATEŞ B (2014). Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats. Turkish Journal of Biology, 38(4), 493 - 501.en_US
dc.identifier.endpage501en_US
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue4en_US
dc.identifier.startpage493en_US
dc.identifier.trdizinid163049en_US
dc.identifier.urihttps://hdl.handle.net/11616/18454
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/163049
dc.identifier.volume38en_US
dc.identifier.wosWOS:000337274500008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherTurkish Journal of Biologyen_US
dc.relation.ispartofTurkish Journal of Biologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleMelatonin is effective in reducing stress-induced organ damage in Wistar albino ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Makale Dosyası.pdf
Boyut:
4.27 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.71 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu