An efficient (NHC) Copper (I)-catalyst for azide-alkyne cycloaddition reactions for the synthesis of 1,2,3-trisubstituted triazoles: Click chemistry
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Sa
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study a series of new benzimidazolium salts (2a-c) were synthesized from the reaction of 5,6-dimethyl-1-(alkylbenzyl)-1H-benzo[d] imidazole with various alkyl halides. These salts were used to synthesize cupper N-heterocyclic carbene (Cu-NHC) complexes 3-4. The obtained (NHC) Copper (I) complexes 3-4 were characterized by FT-IR, NMR (H-1 and C-13) spectroscopic methods, mass spectrometry (EI-MS and HRMS) and elemental analysis. These novel cupper complexes 3-4 were used as a catalyst for alkyne - azide cycloaddition (CuAAC) reaction. Several triazoles 7 have been synthesized. This catalytic system fulfils the requirements of click chemistry with its mild and convenient conditions, notably in water at room temperature with low catalyst loading and simple isolation with no purification step. (C) 2017 Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Alkynes, Azides, Click chemistry, Homogeneous catalysis, Copper-N-heterocyclic carbene complex
Kaynak
Inorganica Chimica Acta
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
467
