Effect of endogen-exogenous melatonin and erythropoietin on dinitrobenzene sulfonic acidinduced colitis

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dc.authoridKAYA, Emin/0000-0001-8605-8497
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authorwosidKAYA, Emin/W-2951-2017
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.contributor.authorTasdemir, Seda
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorVardi, Nigar
dc.contributor.authorKaya, Emin
dc.contributor.authorAcet, Ahmet
dc.date.accessioned2024-08-04T20:37:35Z
dc.date.available2024-08-04T20:37:35Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractInflammatory bowel disease has been linked to elevated T cells. Excessive production of reactive oxygen species and apoptosis are known to be accompanied by intestinal inflammation. This study was designed to investigate the effects of melatonin (MEL) and erythropoietin (EPO), which is a known anti-inflammatory and antiapoptotic agent, in dinitrobenzene sulfonic acid (DNBS)induced colitis in pinealectomized (Px) rats. In microscopically results, epithelial and goblet cell loss, absence of crypts, and increased colonic caspase-3 activity were observed in the DNBS group. Also, in flow cytometric analysis, the percentage of CD4+ T cells was highest in the DNBS group. Treatment with MEL or EPO had a curative effect on DNBS-induced colitis. The MEL+EPO groups showed significantly greater improvement when compared with the other treatment groups. Our results indicate that the combination of EPO and MEL may exert more beneficial effects than either agent used alone.en_US
dc.description.sponsorshipScientific Research Fund of Inonu University, Turkeyen_US
dc.description.sponsorshipThis project was supported by a Grant from Scientific Research Fund of Inonu University, Turkey.en_US
dc.identifier.doi10.1111/j.1472-8206.2011.01016.x
dc.identifier.endpage307en_US
dc.identifier.issn0767-3981
dc.identifier.issn1472-8206
dc.identifier.issue3en_US
dc.identifier.pmid22151426en_US
dc.identifier.scopus2-s2.0-84877836558en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage299en_US
dc.identifier.urihttps://doi.org/10.1111/j.1472-8206.2011.01016.x
dc.identifier.urihttps://hdl.handle.net/11616/96059
dc.identifier.volume27en_US
dc.identifier.wosWOS:000318933000008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofFundamental & Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectapoptosisen_US
dc.subjectcolitisen_US
dc.subjecterythropoietinen_US
dc.subjectmelatoninen_US
dc.subjectpinealectomyen_US
dc.titleEffect of endogen-exogenous melatonin and erythropoietin on dinitrobenzene sulfonic acidinduced colitisen_US
dc.typeArticleen_US

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