The role of valvular and thoracic aortic calcifications in distinction between ischemic and nonischemic cardiomyopathy

Basit Öğe Kaydı
dc.authoridözdemir, özcan/0000-0001-8459-320X;
dc.authorwosidözdemir, özcan/AAZ-3242-2021
dc.authorwosidIleri, Mehmet/A-6525-2018
dc.contributor.authorAtak, R
dc.contributor.authorIleri, M
dc.contributor.authorYetkin, O
dc.contributor.authorYetkin, E
dc.contributor.authorTurhan, H
dc.contributor.authorSenen, K
dc.contributor.authorSahin, O
dc.date.accessioned2024-08-04T20:56:13Z
dc.date.available2024-08-04T20:56:13Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDetermination of underlying etiology in patients with dilated and globally hypokinetic left ventricles may sometimes be difficult even after detailed history and complete clinical evaluation. Cardiac valvular and thoracic aortic calcifications have previously been reported to be used as a window to diffuse atherosclerosis of the vascular system. The authors prospectively examined the predictive value of mitral annular calcification (MAC), aortic valve calcification (AVC), and thoracic aortic calcification (TAC) in diagnosis of coronary artery disease as the underlying cause of diffuse left ventricular dilatation and systolic dysfunction. The study included 98 consecutive patients (male/female = 76/22, mean age = 58.9 +/- 10.7 years, range: 33 to 75 years) over the age of 30 years admitted to their clinics between October 1999 and December 2001 with signs and symptoms of congestive heart failure associated with documented cardiomegaly. Transthoracic echocardiography and coronary angiography were performed in all patients for the evaluation of valvular calcifications and coronary status. Although there was no significant difference between the groups with and without coronary artery stenosis (CAS), with regard to presence of MAC, patients with CAS tended to have MAC more frequently (12/61, 20% vs 4/37, 11%, p > 0.05). AVC and TAC were found to be significantly more frequent in patients with CAS compared to those without CAS (AVC, 35/61, 57% vs 4/37, 11%, p < 0.001 and TAC, 28/61, 46% vs 2/37, 5%, p < 0.001). While all 3 calcifications had sensitivity under 60%, and specificity and positive predictive value over 75% individually, the presence of any of them had a sensitivity of 80%, specificity of 86%, positive predictive value of 91%, and negative predictive value of 73%. Thus the presence of any of these calcifications distinguished patients with coronary artery disease with a sensitivity of 80% and specificity of 86%. The presence of aortic valvular valve and thoracic aortic calcifications seems to be associated with significant coronary arterial stenosis; however, with relatively low negative predictive values these cannot be used in clinical practice for diagnosis of underlying coronary artery disease in patients with dilatated left ventricles and impaired systolic functions.en_US
dc.identifier.doi10.1177/000331970405500607
dc.identifier.endpage667en_US
dc.identifier.issn0003-3197
dc.identifier.issn1940-1574
dc.identifier.issue6en_US
dc.identifier.pmid15547652en_US
dc.identifier.scopus2-s2.0-9244243140en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage661en_US
dc.identifier.urihttps://doi.org/10.1177/000331970405500607
dc.identifier.urihttps://hdl.handle.net/11616/102141
dc.identifier.volume55en_US
dc.identifier.wosWOS:000225443500007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofAngiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary-Artery-Diseaseen_US
dc.subjectIdiopathic Dilated Cardiomyopathyen_US
dc.subjectLeft-Ventricular Dysfunctionen_US
dc.subjectValve Calcificationen_US
dc.subjectMitral Annulusen_US
dc.subjectTl-201en_US
dc.subjectEchocardiographyen_US
dc.subjectDifferentiationen_US
dc.subjectAtherosclerosisen_US
dc.subjectMortalityen_US
dc.titleThe role of valvular and thoracic aortic calcifications in distinction between ischemic and nonischemic cardiomyopathyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu