Oral administration of hesperidin a citrus flavonone in rats counteracts the oxidative stress the inflammatory cytokine production and the hepatotoxicity induced by the ingestion of 2 3 7 8 tetrachlorodibenzo p dioxin TCDD

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dc.authoridTR114386en_US
dc.authoridTR102040en_US
dc.authoridTR52354en_US
dc.authoridTR221903en_US
dc.authoridTR103979en_US
dc.authoridTR34376en_US
dc.contributor.authorBentli, Recep
dc.contributor.authorÇiftçi, Osman
dc.contributor.authorÇetin, Aslı
dc.contributor.authorÜnlü, Merve
dc.contributor.authorBaşak, Neşe
dc.contributor.authorÇay, Mahmut
dc.date.accessioned2017-04-18T06:21:50Z
dc.date.available2017-04-18T06:21:50Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe objective of the current study was to investigate the protective effects of hesperidin against oxidative stress, altered cytokines levels and histological changes in rats induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Rats were divided randomly into four equal groups (Control, TCDD, hesperidin and TCDD+hesperidin). TCDD and hesperidin were given by gavage, dissolved in corn oil at doses of 2 /kg/week and 50 mg/kg/day respectively. The blood and tissue samples were taken from all rats on the 60th day, to be analyzed for the determination of oxidative stress, histological changes and cytokine levels. The results indicated that hesperidin prevented oxidative damage caused by TCDD via decrease lipid peroxidation and increased antioxidant defense systems. It also reversed the histological damage induced by TCDD. Although, TCDD led to a significant increase in TNF- and IL-1 levels, hesperidin treatment was able to normalize these values in rats. In conclusion, it was shown that TCDD caused adverse effects as regards cytokine levels, histological alterations and oxidative stress in rats. However, hesperidin treatment mitigated these toxic effects. These results suggest that hesperidin could play a protective role against TCDD toxicity.en_US
dc.identifier.citationBentli, R. Çiftçi, O. Çetin, A. Ünlü, M. Başak, N. Çay, M. (2013). Oral administration of hesperidin a citrus flavonone in rats counteracts the oxidative stress the inflammatory cytokine production and the hepatotoxicity induced by the ingestion of 2 3 7 8 tetrachlorodibenzo p dioxin TCDD . Eur.Cytokine Netw, 24 -2, 91-96.en_US
dc.identifier.doi10.1684/ecn.2013.0337en_US
dc.identifier.endpage96en_US
dc.identifier.issue2en_US
dc.identifier.startpage91en_US
dc.identifier.urihttps://hdl.handle.net/11616/6683
dc.identifier.volume24en_US
dc.language.isoenen_US
dc.publisherEur.Cytokine Netwen_US
dc.relation.ispartofEur.Cytokine Netwen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTCDDen_US
dc.subjectHesperidinen_US
dc.subjectCytokineen_US
dc.subjectOxidative stressen_US
dc.subjectHistological alterationsen_US
dc.titleOral administration of hesperidin a citrus flavonone in rats counteracts the oxidative stress the inflammatory cytokine production and the hepatotoxicity induced by the ingestion of 2 3 7 8 tetrachlorodibenzo p dioxin TCDDen_US
dc.typeArticleen_US

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