Myocardial ischemia/reperfusion-induced oxidative renal damage in rats: Protection by caffeic acid phenethyl ester (cape)

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dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidCigremis, Yilmaz/JAC-8451-2023
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.contributor.authorOzer, MK
dc.contributor.authorParlakpinar, H
dc.contributor.authorVardi, N
dc.contributor.authorCigremis, Y
dc.contributor.authorUcar, M
dc.contributor.authorAcet, A
dc.date.accessioned2024-08-04T20:14:49Z
dc.date.available2024-08-04T20:14:49Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMyocardial ischemia-reperfusion (MI/R) may induce renal damage. A rat model of M/IR injury was established. The left coronary artery was clamped for 30 min, constituting the ischemic period, and was then released for 120 min, thus constituting the reperfusion period. The purpose of this study was to evaluate the effects of caffeic acid phenethyl ester (CAPE), an antioxidant, on renal dysfunction in rats undergoing MI/R. CAPE (50 mu mol/kg) was administered by infusion 10 min before ischemia and during occlusion. Hemodynamic changes were recorded during the different periods. At the end of the reperfusion period, rats were sacrificed, and the kidneys were quickly removed for biochemical determination and histopathological analysis. MI/R was accompanied by a significant increase in malondialdehyde (MDA) production and decrease in glutathione (GSH) content in the rat kidney. Administration of CAPE reduced MDA production and prevented depletion of GSH content. These beneficial changes in these biochemical parameters were also associated with parallel changes in histopathological appearance. These findings imply that MI/R plays a causal role in kidney injury through overproduction of oxygen radicals or insufficient antioxidant, and CAPE exerts renal-protective effects probably by its radical scavenging and antioxidant activities.en_US
dc.identifier.doi10.1097/01.shk.0000168525.97716.28
dc.identifier.endpage100en_US
dc.identifier.issn1073-2322
dc.identifier.issn1540-0514
dc.identifier.issue1en_US
dc.identifier.pmid15988327en_US
dc.identifier.scopus2-s2.0-21744434732en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage97en_US
dc.identifier.urihttps://doi.org/10.1097/01.shk.0000168525.97716.28
dc.identifier.urihttps://hdl.handle.net/11616/93992
dc.identifier.volume24en_US
dc.identifier.wosWOS:000230257500016en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofShocken_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmyocardial ischemia-reperfusionen_US
dc.subjectrenal injuryen_US
dc.subjectcaffeic acid phenethyl ester (CAPE)en_US
dc.subjectmalondialdehyde (MDA)en_US
dc.subjectglutathione (GSH)en_US
dc.subjectraten_US
dc.titleMyocardial ischemia/reperfusion-induced oxidative renal damage in rats: Protection by caffeic acid phenethyl ester (cape)en_US
dc.typeArticleen_US

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