Factors Affecting eGFR Slope of Renal Transplant Patients During the First 2 Years

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dc.authoridberktas, bayram/0000-0001-9469-4303
dc.authoridtaskapan, hulya/0000-0001-8736-4779
dc.authoridDOGAN, SAIT MURAT/0000-0001-8840-4365
dc.authoridatay, feyza fırat/0000-0002-2841-2985
dc.authorwosidberktas, bayram/ABI-5057-2020
dc.authorwosidPiskin, Turgut/HKV-8614-2023
dc.authorwosidtaskapan, hulya/ABI-7737-2020
dc.authorwosidDOGAN, SAIT MURAT/AAP-7924-2021
dc.authorwosidatay, feyza fırat/AAA-3233-2021
dc.contributor.authorAtay, Feyza Firat
dc.contributor.authorTaskapan, Hulya
dc.contributor.authorBerktas, Bayram
dc.contributor.authorYildirim, Okan
dc.contributor.authorDogan, Murat
dc.contributor.authorPiskin, Turgut
dc.date.accessioned2024-08-04T20:46:45Z
dc.date.available2024-08-04T20:46:45Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description1st International Transplant Network Congress -- OCT 17-21, 2018 -- Antalya, TURKEYen_US
dc.description.abstractPurpose. In healthy individuals, glomerular filtration rate decreases by 1 mL/min/y after a peak level of 125.0 mL/min has been reached in adulthood. Any reduction greater than this is a progressive slope (slope more negative than 1 mL/min/y, stable [-1 to +1]), or an improvable slope if it shows more of an increase, that is, greater than +1.0 mL/min/y). The aim of the study was to determine the factors affecting estimated glomerular filtration rate (eGFR) slope during the first 2 years of renal transplant in patients with negative pretransplant panel-reactive antibody. Materials and Methods. The characteristics of 59 renal transplant patients, such as age, sex, etiology, and 2 years of laboratory data, were collected retrospectively. For each patient, the eGFR decline rate (slope) (mL/min-1/1.73 m(2)-1/y-1) was determined by linear regression analysis using all calculated eGFR values over the study period. Findings. Of 59 patients, 7 (11.8%) had a progressive slope, 22 (37.2%) had a stable slope, and 30 (50.8%) had an improvable slope. The first-year mean tacrolimus level was lower in patients with progressive slope than in the patients with stable slope and improvable slope (P < .022). The determinants of eGFR slope in multiple regression analysis were post-transplant hypertension (beta = 0.393; P = .002) and the first-year mean tacrolimus level (beta = 0.320; P =.01), whereas age, serum albumin, and 2-year mean tacrolimus level did not reach the level of significance. Conclusion. Keeping tacrolimus levels high in the first year to prevent eGFR declining is important.en_US
dc.identifier.doi10.1016/j.transproceed.2019.01.165
dc.identifier.endpage2320en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue7en_US
dc.identifier.pmid31400970en_US
dc.identifier.scopus2-s2.0-85071706658en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2318en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2019.01.165
dc.identifier.urihttps://hdl.handle.net/11616/98937
dc.identifier.volume51en_US
dc.identifier.wosWOS:000487349900042en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKidney-Functionen_US
dc.subjectTacrolimusen_US
dc.titleFactors Affecting eGFR Slope of Renal Transplant Patients During the First 2 Yearsen_US
dc.typeConference Objecten_US

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