Histopathological Examination of Explanted Liver After Transplantation in Patients With Cryptogenic Cirrhosis

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dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridSumer, Fatih/0000-0002-0557-1369
dc.authoridhatipoglu, sinan/0000-0002-4423-084X
dc.authoridKaragul, Servet/0000-0003-1964-2516
dc.authoridKayaalp, Cuneyt/0000-0003-4657-2998
dc.authoridYAYLAK, Faik/0000-0002-1216-0429
dc.authoridKoc, Cemalettin/0000-0002-5676-6772
dc.authorwosidYAYLAK, Faik/AAM-7466-2021
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidSumer, Fatih/F-8042-2017
dc.authorwosidKayaalp, Cuneyt/AAH-1764-2021
dc.authorwosidhatipoglu, sinan/V-9137-2017
dc.authorwosidKaragul, Servet/K-3020-2015
dc.authorwosidKoc, Cemalettin/B-6430-2018
dc.contributor.authorTardu, A.
dc.contributor.authorKaragul, S.
dc.contributor.authorYagci, M. A.
dc.contributor.authorErtugrul, I.
dc.contributor.authorSumer, F.
dc.contributor.authorKirmizi, S.
dc.contributor.authorYaylak, F.
dc.date.accessioned2024-08-04T20:40:18Z
dc.date.available2024-08-04T20:40:18Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives. Cryptogenic cirrhosis is a common indication for liver transplantation. Diagnosis is made after exclusion of other causes of cirrhosis. In this study, the aim was to evaluate patients with cryptogenic cirrhosis after histopathological examination of explanted liver. Materials and Methods. A retrospective histopathological chart review of 117 patients with cryptogenic cirrhosis who had liver transplantation between November 2009 and June 2014 was performed. Age, sex, operative features, survival rates, and preoperative and postoperative diagnosis were evaluated. Results. During the study period, 123 liver transplantations were performed for these 117 patients. Deceased donor liver transplantations were performed in 23 (18.7%) of the cases. Retransplantations were performed in 5 patients. Median age was 48 years, and female-to-male ratio was 41:76. Hepatosteatosis were observed in 29 patients. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis were observed in 20 (12%) and 9 (7.7%) of these patients, respectively. Autoimmune hepatitis was observed in 2 patients. The definitive cause of cirrhosis was unclear in 68 (58%) of the patients. Incidental malignant and premalignant lesions were observed in 15 patients. Conclusions. Histopathological examination of the explanted liver after liver transplantation in those patients with cryptogenic cirrhosis may significantly help to diagnose the cause of cirrhosis, such as nonalcoholic steatohepatitis or autoimmune hepatitis, with using the scoring system developed by the International Autoimmune Hepatitis Workgroup. In addition, incidental malignant or premalignant lesions may be observed.en_US
dc.identifier.doi10.1016/j.transproceed.2015.04.020
dc.identifier.endpage1452en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue5en_US
dc.identifier.pmid26093740en_US
dc.identifier.scopus2-s2.0-84931343976en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1450en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2015.04.020
dc.identifier.urihttps://hdl.handle.net/11616/96828
dc.identifier.volume47en_US
dc.identifier.wosWOS:000357066800052en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiseaseen_US
dc.subjectPrevalenceen_US
dc.subjectSteatohepatitisen_US
dc.subjectDiagnosisen_US
dc.subjectHepatitisen_US
dc.subjectOutcomesen_US
dc.subjectObesityen_US
dc.subjectRisken_US
dc.titleHistopathological Examination of Explanted Liver After Transplantation in Patients With Cryptogenic Cirrhosisen_US
dc.typeArticleen_US

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