The effect of hypericum perforatum on kidney ischemia/reperfusion damage

Basit Öğe Kaydı
dc.authoridCakir, Murat/0000-0002-2066-829X
dc.authoriddemir, samet/0000-0003-4577-0968
dc.authorwosidCakir, Murat/I-8643-2019
dc.authorwosiddemir, samet/K-3166-2017
dc.contributor.authorCakir, Murat
dc.contributor.authorDuzova, Halil
dc.contributor.authorBaysal, Isil
dc.contributor.authorGul, Cemile Ceren
dc.contributor.authorKuscu, Gulbahar
dc.contributor.authorKutluk, Fatma
dc.contributor.authorCakin, Hilal
dc.date.accessioned2024-08-04T20:43:03Z
dc.date.available2024-08-04T20:43:03Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIt has been revealed in recent studies that Hypericum Perforatum (HP) is influential on cancer, inflammatory diseases, bacterial and viral diseases, and has neuroprotective and antioxidant properties. In this study, we investigated the effect of HP, which is known to have antioxidant and anti-inflammatory effects, on kidney I/R damage. Male Sprague-Dawley rats were divided into three groups, and each of the groups had eight rats: The Control Group; the Ischemia/Reperfusion (I/R) Group; and the IR+HP Group which was treated with 50mg/kg of HP. The right kidneys of the rats were removed, and the left kidney developed ischemia during the 45th min, and reperfusion occurred in the following 3rd h. The histopathological findings and also the level of Malondialdehyde (MDA), Glutathione (GSH) and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-PX) enzyme activations in the renal tissues were measured. Blood Urea Nitrogen (BUN), Creatinin (Cre) from serum samples were determined. The levels of BUN, Cre, and kidney tissue MDA increased at a significant level, and the SOD, CAT, and GSH-PX enzyme activity decreased at a significant level in the I/R group, compared with the Control Group (p < 0.05). In the I/R vertical bar HP group, the levels of MDA decreased at a significant level compared to the I/R group, while the SOD, CAT, and GSH-PX activity increased (p < 0.05). In histopathological examinations, it was observed that the tubular dilatation and epithelial desquamation regressed in the IR vertical bar HP Group when compared with the I/R Group. It has been shown with the histological and biochemical results in this study that HP is protective against acute renal I/R.en_US
dc.description.sponsorshipDepartment of Scientific Research Projects of Inonu University [2016/40]en_US
dc.description.sponsorshipThis study was supported by the Department of Scientific Research Projects of Inonu University (Project no: 2016/40).en_US
dc.identifier.doi10.1080/0886022X.2017.1287734
dc.identifier.endpage391en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue1en_US
dc.identifier.pmid28209087en_US
dc.identifier.scopus2-s2.0-85016406491en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage385en_US
dc.identifier.urihttps://doi.org/10.1080/0886022X.2017.1287734
dc.identifier.urihttps://hdl.handle.net/11616/97763
dc.identifier.volume39en_US
dc.identifier.wosWOS:000394441100054en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKidneyen_US
dc.subjectischemia-reperfusionen_US
dc.subjecthypericum perforatumen_US
dc.subjectoxidative stressen_US
dc.subjectraten_US
dc.titleThe effect of hypericum perforatum on kidney ischemia/reperfusion damageen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu