Analysis of Vitamin D Receptor Polymorphisms in Patients with Familial Multiple Sclerosis

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dc.authorscopusid57200215974
dc.authorscopusid8593965900
dc.authorscopusid7101800240
dc.authorscopusid8336109600
dc.authorscopusid55981945400
dc.authorscopusid7006785766
dc.contributor.authorYucel F.E.
dc.contributor.authorKamıslı O.
dc.contributor.authorAcar C.
dc.contributor.authorSozen M.
dc.contributor.authorTecellioğlu M.
dc.contributor.authorOzcan C.
dc.date.accessioned2024-08-04T19:59:23Z
dc.date.available2024-08-04T19:59:23Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Genetic and environmental factors are important in the development of the multiple sclerosis (MS). Vitamin D shows its effects on the immune system with the vitamin D receptor (VDR) in the nucleus. Single nucleotide polymorphisms (SNPs) in the VDR gene can lead to alterations in vitamin D functions and metabolism.Taq I, Apa I, Fok I and Bsm I polymorphisms and MS associations have been investigated in many studies. VDR gene polymorphism has not been previously studied in patients with familial MS.Aim: We aimed to investigate the relationship between familial MS patients present in Turkish population and VDR genotypes Taq I, Apa I and Fok I polymorphisms.Methods: 29 patients with a family history of MS and 120 healthy control subjects were included in the present study. We studied present VDR genotypes Taq I, Apa I and Fok I polymorphisms.Results: We observed a significant difference between controls and patient group only in Taq I polymorphism (p: 0.025). Homozygousity of G allele was not seen in the patients whereas in controls frequency of that genotype was p:0.208. When gender was considered males show significant difference for GG genotype. There were no significant association for the Apa I and Fok I polymorphisms.Conclusion: Although our findings suggest association between VDR Taq I polymorphism and the familial MS, additional studies are needed to establish detailed relationships.en_US
dc.identifier.doi10.5455/medarh.2017.72.58-61
dc.identifier.endpage61en_US
dc.identifier.issn0350-199X
dc.identifier.issue1en_US
dc.identifier.pmid29416220en_US
dc.identifier.scopus2-s2.0-85053542719en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage58en_US
dc.identifier.urihttps://doi.org/10.5455/medarh.2017.72.58-61
dc.identifier.urihttps://hdl.handle.net/11616/90598
dc.identifier.volume72en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofMedical archives (Sarajevo, Bosnia and Herzegovina)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFamilial Multiple Sclerosisen_US
dc.subjectMultiple Sclerosisen_US
dc.subjectVitamin Den_US
dc.subjectVitamin D receptor polymorphismsen_US
dc.titleAnalysis of Vitamin D Receptor Polymorphisms in Patients with Familial Multiple Sclerosisen_US
dc.typeArticleen_US

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