Analysis of Vitamin D Receptor Polymorphisms in Patients with Familial Multiple Sclerosis
dc.authorscopusid | 57200215974 | |
dc.authorscopusid | 8593965900 | |
dc.authorscopusid | 7101800240 | |
dc.authorscopusid | 8336109600 | |
dc.authorscopusid | 55981945400 | |
dc.authorscopusid | 7006785766 | |
dc.contributor.author | Yucel F.E. | |
dc.contributor.author | Kamıslı O. | |
dc.contributor.author | Acar C. | |
dc.contributor.author | Sozen M. | |
dc.contributor.author | Tecellioğlu M. | |
dc.contributor.author | Ozcan C. | |
dc.date.accessioned | 2024-08-04T19:59:23Z | |
dc.date.available | 2024-08-04T19:59:23Z | |
dc.date.issued | 2018 | |
dc.department | İnönü Üniversitesi | en_US |
dc.description.abstract | Objective: Genetic and environmental factors are important in the development of the multiple sclerosis (MS). Vitamin D shows its effects on the immune system with the vitamin D receptor (VDR) in the nucleus. Single nucleotide polymorphisms (SNPs) in the VDR gene can lead to alterations in vitamin D functions and metabolism.Taq I, Apa I, Fok I and Bsm I polymorphisms and MS associations have been investigated in many studies. VDR gene polymorphism has not been previously studied in patients with familial MS.Aim: We aimed to investigate the relationship between familial MS patients present in Turkish population and VDR genotypes Taq I, Apa I and Fok I polymorphisms.Methods: 29 patients with a family history of MS and 120 healthy control subjects were included in the present study. We studied present VDR genotypes Taq I, Apa I and Fok I polymorphisms.Results: We observed a significant difference between controls and patient group only in Taq I polymorphism (p: 0.025). Homozygousity of G allele was not seen in the patients whereas in controls frequency of that genotype was p:0.208. When gender was considered males show significant difference for GG genotype. There were no significant association for the Apa I and Fok I polymorphisms.Conclusion: Although our findings suggest association between VDR Taq I polymorphism and the familial MS, additional studies are needed to establish detailed relationships. | en_US |
dc.identifier.doi | 10.5455/medarh.2017.72.58-61 | |
dc.identifier.endpage | 61 | en_US |
dc.identifier.issn | 0350-199X | |
dc.identifier.issue | 1 | en_US |
dc.identifier.pmid | 29416220 | en_US |
dc.identifier.scopus | 2-s2.0-85053542719 | en_US |
dc.identifier.scopusquality | Q3 | en_US |
dc.identifier.startpage | 58 | en_US |
dc.identifier.uri | https://doi.org/10.5455/medarh.2017.72.58-61 | |
dc.identifier.uri | https://hdl.handle.net/11616/90598 | |
dc.identifier.volume | 72 | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Medical archives (Sarajevo, Bosnia and Herzegovina) | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Familial Multiple Sclerosis | en_US |
dc.subject | Multiple Sclerosis | en_US |
dc.subject | Vitamin D | en_US |
dc.subject | Vitamin D receptor polymorphisms | en_US |
dc.title | Analysis of Vitamin D Receptor Polymorphisms in Patients with Familial Multiple Sclerosis | en_US |
dc.type | Article | en_US |