Activation of coagulation system in dilated cardiomyopathy: comparison of patients with and without left ventricular thrombus

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dc.authorwosidaksoy, yüksel/ABH-1304-2021
dc.contributor.authorErbay, AR
dc.contributor.authorTurhan, H
dc.contributor.authorAksoy, Y
dc.contributor.authorSenen, K
dc.contributor.authorYetkin, E
dc.date.accessioned2024-08-04T20:30:43Z
dc.date.available2024-08-04T20:30:43Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives We aimed to investigate plasma levels of molecular markers for platelet activity, thrombin activation and fibrinolytic status in patients with dilated cardiomyopathy (DCM) with and without left ventricular (LV) thrombus and to compare these markers between patients with DCM and control participants. Materials and methods The study population comprised 60 patients with DCM who met the inclusion criteria. Patients were divided into two groups: 22 patients with LV thrombus and 38 patients without LV thrombus. The age-matched control group consisted of 23 healthy participants (18 men and five women with a mean age of 49). Patients with DCM and healthy participants were compared with respect to platelet activity, thrombin activation and fibrinolytic status. These comparisons were also performed in patients with DCM with and without LV thrombus. Results Platelet factor 4 (28.2+/-4.4 ng/ml compared with 20+/-3.1 ng/ml, P<0.01) and beta-thromboglobulin (40+/-2 ng/ml compared with 17+/-3 ng/ml) levels, reflecting platelet activity, were significantly higher in patients with DCM than in control participants. Fibrinopeptide A (6.94+/-0.69 ng/ml compared with 1.96+/-0.1 ng/ml, P<0.001) and thrombin-antithrombin III complex (5.26+/-2.60 ng/ml compared with 3.17+/-1.23 ng/ml, P<0.001) levels, as markers of fibrin generation, were also higher in patients with DCM than in normal participants. Plasma levels of D-dimer (118+/-16 ng/ml compared with 85+/-3 ng/ml, P<0.001) and plasmin-alpha(2)-plasmin inhibitor complex (0.8+/-1.1 mug/ml compared with 0.6+/-1.7 mug/ml, P<0.001) in patients with DCM significantly exceeded those in the normal participants. There were no statistically significant differences between patients with and without LV thrombus in DCM with respect to platelet activity, thrombin activation and fibrinolytic status. Conclusion We have shown that platelet activation, thrombin activation and fibrinolytic activity are increased in patients with DCM compared to control participants. However, these markers reflecting coagulation activation in patients with LV thrombus are comparable to those in patients without LV thrombus. (C) 2004 Lippincott Williams Wilkins.en_US
dc.identifier.doi10.1097/01.mca.0000135596.54871.6f
dc.identifier.endpage268en_US
dc.identifier.issn0954-6928
dc.identifier.issn1473-5830
dc.identifier.issue5en_US
dc.identifier.pmid15238823en_US
dc.identifier.scopus2-s2.0-4043137326en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage265en_US
dc.identifier.urihttps://doi.org/10.1097/01.mca.0000135596.54871.6f
dc.identifier.urihttps://hdl.handle.net/11616/94480
dc.identifier.volume15en_US
dc.identifier.wosWOS:000223030200008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCoronary Artery Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdilated cardiomyopathyen_US
dc.subjectcoagulation activationen_US
dc.titleActivation of coagulation system in dilated cardiomyopathy: comparison of patients with and without left ventricular thrombusen_US
dc.typeArticleen_US

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