Beneficial Effect of Caffeic Acid Phenethyl Ester (CAPE) on Hepatocyte Damage Induced by Bile Duct Ligation: An Electron Microscopic Examination

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dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.contributor.authorEsrefoglu, Mukaddes
dc.contributor.authorAra, Cengiz
dc.date.accessioned2024-08-04T20:32:33Z
dc.date.available2024-08-04T20:32:33Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractRecently the authors have reported the potent beneficial effect of caffeic acid phenethyl ester (CAPE) on cholestatic oxidative liver injury induced by acute bile ligation in Swiss albino rats. Herein, they report the ultrastructural hepatocellular alterations induced by acute bile duct ligation and the effect of CAPE administration on these alterations. Bile duct ligation resulted in many degenerative changes, such as vacuolization, mitochondrial degeneration, endoplasmic reticulum dilatation, and lysosome accumulation within the cytoplasm of hepatocytes. Mitochondrial degeneration was also observed within the cytoplasm of the cells of biliary ductular epithelium. CAPE potentially protected the hepatocytes from the cholestasis-induced cellular injury.en_US
dc.identifier.doi10.3109/01913121003788729
dc.identifier.endpage278en_US
dc.identifier.issn0191-3123
dc.identifier.issn1521-0758
dc.identifier.issue5en_US
dc.identifier.pmid20568990en_US
dc.identifier.scopus2-s2.0-77957815262en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage273en_US
dc.identifier.urihttps://doi.org/10.3109/01913121003788729
dc.identifier.urihttps://hdl.handle.net/11616/95158
dc.identifier.volume34en_US
dc.identifier.wosWOS:000282644500005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofUltrastructural Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCholestatic Oxidative Stressen_US
dc.subjectKappa-Ben_US
dc.subjectLiveren_US
dc.subjectMelatoninen_US
dc.subjectMitochondriaen_US
dc.subjectApoptosisen_US
dc.subjectInjuryen_US
dc.subjectRaten_US
dc.titleBeneficial Effect of Caffeic Acid Phenethyl Ester (CAPE) on Hepatocyte Damage Induced by Bile Duct Ligation: An Electron Microscopic Examinationen_US
dc.typeArticleen_US

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