Guided bone regeneration with polyethylene membrane, zoledronic acid and hydroxiapatide bone graft in peri-implant bone defect: An experimental study

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dc.authoridÖZERCAN, ibrahim Hanifi/0000-0002-8781-8838
dc.authoridKIRTAY, Mustafa/0000-0003-2568-7470
dc.authorwosidÖZERCAN, ibrahim Hanifi/W-7883-2018
dc.authorwosidCakmak, Omer/W-4556-2017
dc.authorwosidKÖM, Mustafa/V-9732-2018
dc.authorwosidDundar, Serkan/V-8159-2018
dc.authorwosidKaya, Beyza/KIG-8134-2024
dc.authorwosidKIRTAY, Mustafa/ABA-7066-2021
dc.contributor.authorYaman, Ferhan
dc.contributor.authorDundar, Serkan
dc.contributor.authorCakmak, Omer
dc.contributor.authorSaybak, Arif
dc.contributor.authorKirtay, Mustafa
dc.contributor.authorKaya, Beyza
dc.contributor.authorKom, Mustafa
dc.date.accessioned2024-08-04T20:43:04Z
dc.date.available2024-08-04T20:43:04Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study aimed to determine the guided bone regeneration (GBR) capacity of peri-implant bone defect treatment, either with only a hydroxyapatite bone graft or with a hydroxyapatite bone graft mixed with zoledronic acid (ZA) and employing polyethylene glycol (PEG) barrier membranes. In this study, four male New Zealand rabbits were used. First, the rabbits were randomly divided into two groups, the hydroxyapatite graft group (HA) (n=2) and the HA graft + zoledronic acid group (HA+ZA) (n=2). For the HA group, peri-implant GBR was performed with only an HA bone graft, and a resorbable PEG barrier membrane was placed over each surgical defect to cover the peri-implant bone defects. For the HA+ZA group, peri-implant GBR was performed with an HA bone graft that had previously been mixed with ZA. A resorbable PEG barrier membrane was placed over each surgical defect to cover the peri-implant bone defects. Experiments were performed using a standardised peri-implant bone tissue defect model in rabbit tibia for 60 days. Circumferential defects were surgically induced around the dental implants on the tibias of four rabbits. Sixty days after the surgical procedures, the rabbits were sacrificed, and their tibias with the graft sites were harvested for histologic evaluation. In the HA+ZA group, significantly more new bone formation was detected as compared with the HA group (P<0.05). Within the limitations of this study, locally administered ZA with an HA synthetic graft and PEG membrane was a more effective method as compared to using only a graft in a peri-implant GBR procedure. Additionally, a PEG membrane should be useful in GBR as a barrier membrane. Further studies are needed to confirm these results.en_US
dc.identifier.endpage2688en_US
dc.identifier.issn0970-938X
dc.identifier.issn0976-1683
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85017110494en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2684en_US
dc.identifier.urihttps://hdl.handle.net/11616/97775
dc.identifier.volume28en_US
dc.identifier.wosWOS:000403448200055en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAllied Acaden_US
dc.relation.ispartofBiomedical Research-Indiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPeriimplant bone defecten_US
dc.subjectGuided bone regenerationen_US
dc.subjectSynthetic bone graften_US
dc.subjecthydroxiapatideen_US
dc.subjectZoledronic aciden_US
dc.titleGuided bone regeneration with polyethylene membrane, zoledronic acid and hydroxiapatide bone graft in peri-implant bone defect: An experimental studyen_US
dc.typeArticleen_US

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