Effect of nebivolol on liver regeneration in an experimental 70% partial hepatectomy model

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dc.authoridSumer, Fatih/0000-0002-0557-1369;
dc.authorwosidSumer, Fatih/F-8042-2017
dc.authorwosidözşay, oğuzhan/AAO-1440-2021
dc.authorwosidÇolakoğlu, Muhammet/GZL-7705-2022
dc.authorwosidBostancı, Erdal Birol/HJP-0581-2023
dc.contributor.authorSumer, Fatih
dc.contributor.authorColakoglu, Muhammet Kadri
dc.contributor.authorOzdemir, Yilmaz
dc.contributor.authorOzsay, Oguzhan
dc.contributor.authorIlter, Ozer
dc.contributor.authorBostanci, Erdal Birol
dc.contributor.authorAkoglu, Musa
dc.date.accessioned2024-08-04T20:41:45Z
dc.date.available2024-08-04T20:41:45Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Factors affecting liver regeneration are still relevant. The purpose of this study is to investigate the effect of nebivolol treatment on liver regeneration in rats in which 70% partial hepatectomy was performed. Methods: Three groups were created: the control group, the low dose group, and the high dose group, with 20 rats in each group and 70% hepatectomy was performed in all rats. Immediately after partial liver resection, 2 mL physiological saline solution was administered to the control group via oral gavage, 0.5 mg/kg nebivolol was administered via oral gavage to the low dose group and 2 mg/kg nebivolol was administered via oral gavage to the high dose group. On the 1st and 5th days after liver resection, 10 subjects were sacrificed from each group, and liver weights and the mitotic count and Ki-67 were measured. Results: Regenerating liver weight on the 1st and 5th days after partial hepatectomy was statistically different in the low dose and high dose nebivolol groups compared to the control group. Mitotic count on the 1st day after partial hepatectomy was significantly higher in the low dose and high dose nebivolol groups than the control group. There was no statistically significant difference detected between the three groups for the 5th day. On the 1st day, Ki-67 rates were significantly higher in both groups given nebivolol than the control group. However, 5th day results were not statistically significant. Conclusion: Nebivolol increases regeneration after partial hepatectomy in rats. (C) 2016 Asian Surgical Association and Taiwan Robotic Surgical Association. Publishing services by Elsevier B.V.en_US
dc.identifier.doi10.1016/j.asjsur.2015.12.005
dc.identifier.endpage379en_US
dc.identifier.issn1015-9584
dc.identifier.issn0219-3108
dc.identifier.issue5en_US
dc.identifier.pmid26920216en_US
dc.identifier.scopus2-s2.0-84966378397en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage375en_US
dc.identifier.urihttps://doi.org/10.1016/j.asjsur.2015.12.005
dc.identifier.urihttps://hdl.handle.net/11616/97312
dc.identifier.volume40en_US
dc.identifier.wosWOS:000423447300008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Singapore Pte Ltden_US
dc.relation.ispartofAsian Journal of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectliver regenerationen_US
dc.subjectnebivololen_US
dc.subjectpartial hepatectomyen_US
dc.titleEffect of nebivolol on liver regeneration in an experimental 70% partial hepatectomy modelen_US
dc.typeArticleen_US

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