Ultrastructural changes in epithelial cells of rats exposed to low concentration of hydrogen sulfide for 50 days

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dc.authoridKOTİL, TUĞBA/0000-0003-1261-0597
dc.authoridözdemir, hakan/0000-0001-9550-1999
dc.authoridKOTİL, TUĞBA/0000-0003-1261-0597
dc.authoridAydin, Murat/0000-0003-0030-8999
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridhocaoglu, turgay peyami/0000-0002-0281-8928
dc.authorwosidKOTİL, TUĞBA/AAH-7572-2019
dc.authorwosidKotil, Tuğba/L-3783-2016
dc.authorwosidözdemir, hakan/IXE-1202-2023
dc.authorwosidOzdemir, Hakan/AAG-3194-2021
dc.authorwosidKOTİL, TUĞBA/IWE-5331-2023
dc.authorwosidAydin, Murat/HCI-8580-2022
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.contributor.authorYeler, Defne Yalcin
dc.contributor.authorAydin, Murat
dc.contributor.authorHocaoglu, Peyami Turgay
dc.contributor.authorKoraltan, Melike
dc.contributor.authorOzdemir, Hakan
dc.contributor.authorKotil, Tugba
dc.contributor.authorGul, Mehmet
dc.date.accessioned2024-08-04T20:42:42Z
dc.date.available2024-08-04T20:42:42Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHydrogen sulfide (H2S) and other volatile sulfur compounds (VSCs) appear mainly in the oral air of patients with halitosis. It seems that VSCs are directly involved in the pathogenesis of gingival diseases. In previous studies, short-term (7 hours-4 days), high concentrations (5-400 ppm) of H2S applications on periodontal tissues have been evaluated in a culture medium. The aim of the present study was to investigate the potential effects of lower (equivalent to halitosis) concentrations of H2S on rat gingival tissue for longer-term inhalation. The threshold level of pathologic halitosis perceived by humans at 250 ppb of H2S was converted to rat equivalent concentration (4.15 ppm). Rats in the experimental (H2S) group (n=8) were exposed to H2S continuously but not the control rats (n=8). After 50 days, the gingival sulcular tissue samples of each rat were taken and examined using transmission electron microscope. Ultrastructural changes in the sulcular epithelia of the rat gingiva showed deformation of celullar shape, vacuolization, and disintegrity of intercelullar connection by loss of desmosomes and collagen fibrils. No basal membrane damage was observed. Inhalation of low levels of H2S (equivalent of halitosis) in the oral environment causes ultrastructural celullar damages in rat sulcular mucosa. These results suggest that halitosis may be the potential reason for periodontal destruction in humans.en_US
dc.description.sponsorshipScientific Research Project Fund of Cumhuriyet University [Dis-106]en_US
dc.description.sponsorshipThis research was supported by the Scientific Research Project Fund of Cumhuriyet University under the project number Dis-106.en_US
dc.identifier.doi10.1080/01913123.2016.1234530
dc.identifier.endpage357en_US
dc.identifier.issn0191-3123
dc.identifier.issn1521-0758
dc.identifier.issue6en_US
dc.identifier.pmid27736270en_US
dc.identifier.scopus2-s2.0-84991036027en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage351en_US
dc.identifier.urihttps://doi.org/10.1080/01913123.2016.1234530
dc.identifier.urihttps://hdl.handle.net/11616/97532
dc.identifier.volume40en_US
dc.identifier.wosWOS:000389178600007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofUltrastructural Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDesmosomen_US
dc.subjecthalitosisen_US
dc.subjecthydrogene sulfideen_US
dc.subjectsulcular tissueen_US
dc.subjectvacuolizationen_US
dc.titleUltrastructural changes in epithelial cells of rats exposed to low concentration of hydrogen sulfide for 50 daysen_US
dc.typeArticleen_US

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