Effects of some probable antioxidants on selenite-induced cataract formation and oxidative stress-related parameters in rats

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dc.authoridOrhan, Hilmi/0000-0003-2464-1841
dc.authoridŞahin, Gönül/0000-0003-3742-6841
dc.authorwosidOrhan, Hilmi/ABD-6164-2021
dc.authorwosidŞahin, Gönül/AAC-3383-2019
dc.contributor.authorOrhan, H
dc.contributor.authorMarol, S
dc.contributor.authorHepsen, IF
dc.contributor.authorSahin, G
dc.date.accessioned2024-08-04T20:12:00Z
dc.date.available2024-08-04T20:12:00Z
dc.date.issued1999
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe effect of several natural and synthetic compounds on selenite-induced cataract was investigated in rat pups. Simultaneous determination of glutathione S-transferase (GST), selenium dependent glutathione peroxidase (Se-GPx), catalase (CAT), superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels were carried out in the lens, erythrocyte and plasma. The results showed that propolis, diclofenac, vitamin C (Vit-C) and quercetin prevented cataract formation to the extent of 70, 60, 58.4, and 40%, respectively. Standardized extract of Ginkgo biloba (Egb 761) did not affect the cataract formation. Selenite treatment caused a significant decrease in the activity of erythrocyte SOD. This was accompanied by a simultaneous increase in the levels of MDA either in lens and in plasma. A significant increase was shown in erythrocyte GST (substrate ethacrynic acid; eaa), and GPx activities and lens GST (substrate chlorodinitro benzene; cdnb) activity. Antioxidant treatment caused significant changes in enzyme activities and MDA levels. There was no effect of selenite and antioxidants on total body weight increase during the course of the study. Blood parameters did not correlate to lens parameters following selenite treatment. Our results suggest that antioxidant supplementation following selenite exposure may prevent the cataract formation and may enhance antioxidant defence of blood and lens. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/S0300-483X(99)00128-6
dc.identifier.endpage232en_US
dc.identifier.issn0300-483X
dc.identifier.issn1879-3185
dc.identifier.issue3en_US
dc.identifier.pmid10647922en_US
dc.identifier.scopus2-s2.0-0032760299en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage219en_US
dc.identifier.urihttps://doi.org/10.1016/S0300-483X(99)00128-6
dc.identifier.urihttps://hdl.handle.net/11616/93152
dc.identifier.volume139en_US
dc.identifier.wosWOS:000084471200003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofToxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectin vivoen_US
dc.subjectraten_US
dc.subjectseleniteen_US
dc.subjectanticataracten_US
dc.subjectlensen_US
dc.subjecterythrocyteen_US
dc.subjectantioxidant enzymesen_US
dc.subjectplant extractsen_US
dc.subjectdiclofenacen_US
dc.subjectvitamin Cen_US
dc.titleEffects of some probable antioxidants on selenite-induced cataract formation and oxidative stress-related parameters in ratsen_US
dc.typeArticleen_US

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