(3R, 3'R)-zeaxanthin protects the retina from photo-oxidative damage via modulating the inflammation and visual health molecular markers

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dc.authoridSahin, Kazim/0000-0001-9542-5244
dc.authoridsahin, nurhan/0000-0001-9487-1154
dc.authoridGENCOGLU, HASAN/0000-0002-7716-552X
dc.authoridÖZERCAN, ibrahim Hanifi/0000-0002-8781-8838
dc.authoridOrhan, Cemal/0000-0003-4138-7689
dc.authoridAkdemir, Fatih/0000-0002-5779-6631
dc.authoridTuzcu, Mehmet/0000-0002-1329-3143
dc.authorwosidSahin, Kazim/D-5625-2009
dc.authorwosidsahin, nurhan/ABF-8007-2020
dc.authorwosidGENCOGLU, HASAN/Q-2668-2015
dc.authorwosidÖZERCAN, ibrahim Hanifi/W-7883-2018
dc.authorwosidOrhan, Cemal/Q-2086-2015
dc.authorwosidAkdemir, Fatih/AAG-8010-2019
dc.authorwosidTuzcu, Mehmet/H-2953-2018
dc.contributor.authorSahin, Kazim
dc.contributor.authorAkdemir, Fatih
dc.contributor.authorOrhan, Cemal
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorGencoglu, Hasan
dc.contributor.authorSahin, Nurhan
dc.contributor.authorOzercan, Ibrahim H.
dc.date.accessioned2024-08-04T20:45:42Z
dc.date.available2024-08-04T20:45:42Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: Zeaxanthin protects the macula from ocular damage due to light or radiation by scavenging harmful reactive oxygen species. In the present study, zeaxanthin product (OmniXan (R); OMX), derived from paprika pods (Capsicum annum; Family-Solanaceae), was tested for its efficacy in the rat retina against photooxidation. Methods: Forty-two male 8-week-old Wistar rats exposed to 12L/12D, 16L/8D and 24L/0D hours of intense light conditions were orally administrated either 0 or 100 mg/kg BW of zeaxanthin concentration. Retinal morphology was analyzed by histopathology, and target gene expressions were detected with real-time polymerase chain reaction methods. Results: OMX treatment significantly increased the serum zeaxanthin concentration (p < 0.001) and ameliorated oxidative damage by increasing the antioxidant enzyme activities in the retina induced by light (p < 0.001). OMX administration significantly upregulated the expression of genes, including Rhodopsin (Rho), Rod arrestin (SAG), G alpha Transducin 1 (GNAT-1), neural cell adhesion molecule (NCAM), growth-associated protein 43 (GAP43), nuclear factor-(erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase (HO-1) and decreased the expression of nuclear factor-kappa B (NF- kappa B) and GFAP by OMX treatment rats. The histologic findings confirmed the antioxidant and gene expression data. Conclusions: This study suggests that OMX is a potent substance that can be used to protect photoreceptor cell degeneration in the retina exposed to intense light.en_US
dc.description.sponsorshipOmniactive Health Technologies (NJ, USA); Turkiye Bilimler Akademisi (Ankara, Turkey)en_US
dc.description.sponsorshipThis study was supported by the Omniactive Health Technologies (NJ, USA) and partially supported by the Turkiye Bilimler Akademisi (Ankara, Turkey).en_US
dc.identifier.doi10.1080/15569527.2018.1554667
dc.identifier.endpage168en_US
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue2en_US
dc.identifier.pmid30513212en_US
dc.identifier.scopus2-s2.0-85060830119en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage161en_US
dc.identifier.urihttps://doi.org/10.1080/15569527.2018.1554667
dc.identifier.urihttps://hdl.handle.net/11616/98631
dc.identifier.volume38en_US
dc.identifier.wosWOS:000463785000009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofCutaneous and Ocular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLight-emitting diode (LED)en_US
dc.subjectoxidative stressen_US
dc.subjectphoto-oxidationen_US
dc.subjectretinaen_US
dc.subjectzeaxanthinen_US
dc.title(3R, 3'R)-zeaxanthin protects the retina from photo-oxidative damage via modulating the inflammation and visual health molecular markersen_US
dc.typeArticleen_US

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