Altered diurnal variation of nitric oxide production in patients with panic disorder

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dc.authoridUnal, Suheyla/0000-0003-3266-6256
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridUNAL, SERHAT/0000-0003-1184-4711
dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authoridUnal, Suheyla/0000-0003-3266-6256
dc.authorwosidUnal, Suheyla/JVO-8367-2024
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidUNAL, SERHAT/I-9034-2013
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.authorwosidUnal, Suheyla/HJH-7559-2023
dc.contributor.authorKaya, B
dc.contributor.authorÜnal, S
dc.contributor.authorKarabulut, AB
dc.contributor.authorTürköz, Y
dc.date.accessioned2024-08-04T20:30:58Z
dc.date.available2024-08-04T20:30:58Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this prospective study was to investigate the diurnal change in serum nitric oxide (NO) levels in active and remission phases of patients with panic disorder. This study included 15 patients fulfilling the criteria for panic disorder of Diagnostic and Statistical Manual of Mental Disorders - Fourth Edition and 15 healthy controls matched for age and sex. All patients were receiving a selective serotonin reuptake inhibitor at therapeutic doses. The serum nitrite and nitrate levels of subjects were determined at 10: 00 a.m. after overnight fasting and at 3: 00 p.m. 2 hours after lunch. NO levels of all patients measured in the morning were significantly higher than those of controls. The patients were also divided into active and remission groups according to clinical status and Panic Agoraphobia Scale's cut-off point. There were no statistically significant differences in serum nitrite and nitrate levels of the active group between the 10:00 a.m. and 3:00 p.m. measurements. In contrast, statistically significant differences were found in the serum levels of nitrite (p<0.05) and nitrate (p<0.05) in the remission group. Notably, the afternoon nitrite and nitrate levels of the remission group were higher than those of the morning levels as seen in control subjects. Thus, diurnal variation of NO production is altered in patients with panic disorder but is resumed in the remission phase. The present study suggests that serum NO levels are a good marker for evaluation of panic disorder. (C) 2004 Tohoku University Medical Press.en_US
dc.identifier.doi10.1620/tjem.204.147
dc.identifier.endpage154en_US
dc.identifier.issn0040-8727
dc.identifier.issn1349-3329
dc.identifier.issue2en_US
dc.identifier.pmid15383695en_US
dc.identifier.scopus2-s2.0-5044235808en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage147en_US
dc.identifier.urihttps://doi.org/10.1620/tjem.204.147
dc.identifier.urihttps://hdl.handle.net/11616/94640
dc.identifier.volume204en_US
dc.identifier.wosWOS:000223987800006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTohoku Univ Medical Pressen_US
dc.relation.ispartofTohoku Journal of Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectoxidative stressen_US
dc.subjectnitric oxideen_US
dc.subjectdiurnalityen_US
dc.subjectpanic disorderen_US
dc.subjectSSRIen_US
dc.titleAltered diurnal variation of nitric oxide production in patients with panic disorderen_US
dc.typeArticleen_US

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