Ginkgo biloba prevents mobile phone-induced oxidative stress in rat brain

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dc.authoridKamisli, Suat/0000-0003-4281-3301
dc.authoridArmutcu, Ferah/0000-0002-3218-9480;
dc.authorwosidKamisli, Suat/JVN-4663-2024
dc.authorwosidKamisli, Suat/AAC-2706-2021
dc.authorwosidArmutcu, Ferah/A-1364-2019
dc.authorwosidKamisli, Suat/JZT-8388-2024
dc.contributor.authorIlhan, A
dc.contributor.authorGurel, A
dc.contributor.authorArmutcu, F
dc.contributor.authorKamisli, S
dc.contributor.authorIraz, M
dc.contributor.authorAkyol, O
dc.contributor.authorOzen, S
dc.date.accessioned2024-08-04T20:13:37Z
dc.date.available2024-08-04T20:13:37Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The widespread use of mobile phones (MP) in recent years has raised the research activities in many countries to determine the consequences of exposure to the low-intensity electromagnetic radiation (EMR) of mobile phones. Since several experimental studies suggest a role of reactive oxygen species (ROS) in EMR-induced oxidative damage in tissues, in this study, we investigated the effect of Ginkgo biloba (Gb) on MP-induced oxidative damage in brain tissue of rats. Methods: Rats (EMR+) were exposed to 900 MHz EMR from NIP for 7 days (1 h/day). In the EMR + Gb groups, rats were exposed to EMR and pretreated with Gb. Control and Gb-administrated groups were produced by turning off the mobile phone while the animals were in the same exposure conditions. Subsequently, oxidative stress markers and pathological changes in brain tissue were examined for each groups. Results: Oxidative damage was evident by the: (i) increase in malondialdehyde (MDA) and nitric oxide (NO) levels in brain tissue, (ii) decrease in brain superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities and (iii) increase in brain xanthine oxidase (XO) and adenosine deaminase (ADA) activities. These alterations were prevented by Gb treatment. Furthermore, Gb prevented the MP-induced cellular injury in brain tissue histopathologically. Conclusion: Reactive oxygen species may play a role in the mechanism that has been proposed to explain the biological side effects of MP, and Gb prevents the MP-induced oxidative stress to preserve antioxidant enzymes activity in brain tissue. (C) 2003 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.cccn.2003.10.012
dc.identifier.endpage162en_US
dc.identifier.issn0009-8981
dc.identifier.issn1873-3492
dc.identifier.issue1-2en_US
dc.identifier.pmid14734207en_US
dc.identifier.scopus2-s2.0-0842281428en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage153en_US
dc.identifier.urihttps://doi.org/10.1016/j.cccn.2003.10.012
dc.identifier.urihttps://hdl.handle.net/11616/93740
dc.identifier.volume340en_US
dc.identifier.wosWOS:000188884500015en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofClinica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmobile phoneen_US
dc.subjectfree radicalsen_US
dc.subjectoxidative damageen_US
dc.subjectdark neuronen_US
dc.subjectbrain tissueen_US
dc.subjectGinkgo bilobaen_US
dc.titleGinkgo biloba prevents mobile phone-induced oxidative stress in rat brainen_US
dc.typeArticleen_US

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