Sulfonated N-heterocyclic carbine-silver (I) complexes: Synthesis, characterisation and biological evaluation

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dc.authoridYaşar, Sedat/0000-0001-7285-2761
dc.authoridKul Koprulu, Tugba/0000-0001-9451-5715
dc.authorwosidYaşar, Sedat/ABG-8356-2020
dc.authorwosidYaşar, Şeyma/ABI-8055-2020
dc.authorwosidKul Koprulu, Tugba/U-7334-2017
dc.contributor.authorYasar, Seyma
dc.contributor.authorKoprulu, Tugba Kul
dc.contributor.authorTekin, Saban
dc.contributor.authorYasar, Sedat
dc.date.accessioned2024-08-04T20:43:59Z
dc.date.available2024-08-04T20:43:59Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe synthesis, characterisation and biological activity of water-soluble Ag(I)-NHC complexes, general formula Na[(NHC)AgCl] where NHC is a sulfonated and sterically hindered N-heterocyclic carbene, is reported. The Ag-NHC complexes (2a-e) were synthesised by reacting the corresponding sulfonated NHC ligands with Ag2O in the presence of NaCl or NaBr in methanol/water (1:1) solution. Synthesised silver (I)-N-heterocyclic carbene complexes have been characterised by NMR, micro-analysis and HRMS spectroscopic methods. The IC50 values of these complexes were determined by a proliferation BrdU enzyme-linked immunosorbent assay (ELISA) against HeLa (human cervix carcinoma), HT29 (human adenocarcinoma) and L929 (mouse fibroblast) cell lines. These complexes have been highlighted as promising and original platforms for building new types of metalodrug. All new water-soluble Ag(I) complexes demonstrated remarkable cytotoxic activity against HeLa, HT29 and L929 cell lines.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [114Z036]en_US
dc.description.sponsorshipThis work was financially supported by The Scientific and Technological Research Council of Turkey (TUBITAK Project no.: 114Z036).en_US
dc.identifier.doi10.1002/aoc.4016
dc.identifier.issn0268-2605
dc.identifier.issn1099-0739
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85029440954en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/aoc.4016
dc.identifier.urihttps://hdl.handle.net/11616/97965
dc.identifier.volume32en_US
dc.identifier.wosWOS:000423670000024en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofApplied Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanticancer activityen_US
dc.subjectapoptosisen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectsulfonated N-heterocyclic carbineen_US
dc.subjectwater-soluble silver complexen_US
dc.titleSulfonated N-heterocyclic carbine-silver (I) complexes: Synthesis, characterisation and biological evaluationen_US
dc.typeArticleen_US

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