Protective effect of dexpanthenol on gentamicin-induced nephrotoxicity in rats
| dc.contributor.author | Pinar, Neslihan | |
| dc.contributor.author | Ozcan, Oguzhan | |
| dc.contributor.author | Dogan, Esin | |
| dc.contributor.author | Cakirca, Gokhan | |
| dc.date.accessioned | 2022-03-07T16:52:13Z | |
| dc.date.available | 2022-03-07T16:52:13Z | |
| dc.date.issued | 2019 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Aim: We evaluated the protective effects of dexpanthenol (Dxp) in rats with gentamicin (Genta)-induced nephrotoxicity by assessing a panel of biochemical and histopathologic parameters.Material Methods: Forty rats were divided randomly into the following four groups: Control group, physiological saline solution (0.5 cc intraperitoneally (i.p.) for 8 days; Dxp group, Dxp (500 mg/kg i.p.) for 8 days; Genta group, Genta (100 mg/kg, i.p.) for 8 days; and Genta+Dxp group, Gent a and Dxp (100 and 500 mg/kg i.p., respectively) for 8 days.Results: TIn the Genta group, the urea, creatinine, tumor necrosis factor-alpha (TNF-α), total oxidant status (TOS), oxidative stress index (OSI) and malondialdehyde (MDA) levels were significantly higher and the catalase (CAT) and glutathione peroxidase (GSH-Px) activities were significantly lower than those in the control group. In the Genta+Dxp group, the urea, creatinine, and TNF-α, TOS, OSI and MDA levels were significantly lower and the CAT and GSH-Px activities were significantly higher than those in the Genta group. Histopathological investigation showed severe tubular necrosis in the Genta group, which was of lesser severity in the Genta+Dxp group. Conclusion: The biochemical and histopathologic results of this study indicate that Dxp can ameliorate Genta-induced nephrotoxicity.Keywords: Oxidative stress; antioxidant; gentamicin; nephrotoxicity; dexpanthenol. | en_US |
| dc.identifier.citation | Pinar, N., Ozcan, O., Dogan, E., & Cakirca, G. (2021). Protective effect of dexpanthenol on gentamicin-induced nephrotoxicity in rats . Annals of Medical Research | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/54565 | |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Annals of Medical Research | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Protective effect of dexpanthenol on gentamicin-induced nephrotoxicity in rats | en_US |
| dc.type | Article | en_US |
