Tissue Heavy Metals in Liver Diseases

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dc.authoridUremis, Muhammed Mehdi/0000-0003-2296-2422
dc.authoridSARICI, KEMAL BARIŞ/0000-0001-9595-1906
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authorwosidUremis, Muhammed Mehdi/HKP-0531-2023
dc.authorwosidSARICI, KEMAL BARIŞ/ABI-4356-2020
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.contributor.authorAkbulut, Sami
dc.contributor.authorIsik, Burak
dc.contributor.authorUremis, Muhammed Mehdi
dc.contributor.authorDogan, Ufuk Gunay
dc.contributor.authorSahin, Tevfik Tolga
dc.contributor.authorSarici, Kemal Baris
dc.contributor.authorKoc, Cemalettin
dc.date.accessioned2024-08-04T20:52:15Z
dc.date.available2024-08-04T20:52:15Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. Our objective was to determine the levels of heavy metals, oxidants, and antioxidants in liver tissue of patients with chronic liver disease (CLD) compared with healthy living liver donors (LLDs). Methods. We obtained liver specimens from patients undergoing liver transplant for CLD. Samples were also obtained from LLDs. Biochemical analyses were performed on all samples, and the levels of liver tissue, heavy metal, and oxidant-antioxidants biomarker levels in patients with CLD were compared with those measured in LLDs. Results. One hundred and eighteen individuals were included for analyses. Fifty-nine were patients with CLD, and 59 were LLDs. The median levels of liver tissue of superoxide dismutase (P =.009), glutathione peroxidase (P =.042), total oxidant status (P =.006), oxidative stress index (P <.001), and copper (P =.035) were prominently more elevated in CLD than LLDs. On the other hand, the median levels of liver tissue of cadmium (P <.001), selenium (P =.042), and zinc (P <.001) levels were more elevated in the LLDs than patients with CLD. The 2 groups were similar in terms of total antioxidant status, manganese, arsenic, and lead levels. Conclusions. Superoxide accumulation in the liver was higher in patients with CLD. Concerning heavy metals, only the median tissue copper was elevated in patients with CLD with higher Cu/Zn ratio. Cadmium, selenium, and zinc were significantly higher in the healthy LLDs.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Coordination Unit [2018/1320]en_US
dc.description.sponsorshipSupported by Inonu University Scientific Research Projects Coordination Unit (Project No: 2018/1320).en_US
dc.identifier.doi10.1016/j.transproceed.2022.05.029
dc.identifier.endpage1864en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue7en_US
dc.identifier.pmid35985878en_US
dc.identifier.scopus2-s2.0-85136083062en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1859en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2022.05.029
dc.identifier.urihttps://hdl.handle.net/11616/100847
dc.identifier.volume54en_US
dc.identifier.wosWOS:001005421300028en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxidative Stressen_US
dc.subjectFree-Radicalsen_US
dc.subjectCadmiumen_US
dc.subjectZincen_US
dc.subjectExposureen_US
dc.subjectSamplesen_US
dc.subjectAntioxidantsen_US
dc.subjectToxicityen_US
dc.subjectSeleniumen_US
dc.subjectLungen_US
dc.titleTissue Heavy Metals in Liver Diseasesen_US
dc.typeArticleen_US

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