Hesperidin, a Citrus Flavonoid, Has the Ameliorative Effects Against Experimental Autoimmune Encephalomyelitis (EAE) in a C57BL/J6 Mouse Model

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dc.authoridKamisli, Ozden/0000-0003-1114-7860
dc.authoridKamisli, Ozden/0000-0003-1114-7860
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridozcan, abdulcemal/0000-0002-6759-7556
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidKamisli, Ozden/AAA-6553-2020
dc.authorwosidKamisli, Ozden/JVZ-0145-2024
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidozcan, abdulcemal/B-1348-2008
dc.contributor.authorCiftci, Osman
dc.contributor.authorOzcan, Cemal
dc.contributor.authorKamisli, Ozden
dc.contributor.authorCetin, Asli
dc.contributor.authorBasak, Nese
dc.contributor.authorAytac, Bilal
dc.date.accessioned2024-08-04T20:40:17Z
dc.date.available2024-08-04T20:40:17Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was determined the effects of Hesperidin (HP) on neuronal damage in brain tissue caused by Experimental allergic encephalomyelitis (EAE), an established model of multiple sclerosis in C57BL/J6 mice. To explore 40 mice were equally divided into four groups: (1) Control, (2) EAE, (3) HP, and (4) HP + EAE. 14 days after induction of EAE with MOG35-55 and pertussis toxin, the mice treated with HP at the doses of 50 mg/kg/day for 7 days subcutaneously. To our results HP treatment prevents the oxidative stress caused by EAE via a decrease in lipid peroxidations and increase in elements of the antioxidant defense systems in brain tissue. Also, EAE elevate the IL-17, express the pro-inflammatory cytokines, and caspase-3-like immunreactivity, show apoptosis, staining in EAE mice brain and increased the incidence of histopathological damage. However, immonohistochemical and histological changes were reversed with HP. Moreover, elevated TNF-alpha and IL-1 beta levels, a result of EAE, were decreased in serum and neurological deficits as clinical signs were reversed with HP treatment in EAE mice, given HP. In conclusion, HP treatment effectively prevents oxidative, immunological and histological damage in the brain caused by EAE. It was thought that the beneficial effects of HP are likely a result of its strong antioxidant and anti-inflammatory properties.en_US
dc.description.sponsorshipIUBAP (Scientific Research Fund of Inonu University) [2013/205]en_US
dc.description.sponsorshipWe acknowledge the financial support of IUBAP (Scientific Research Fund of Inonu University) under Grant 2013/205.en_US
dc.identifier.doi10.1007/s11064-015-1571-8
dc.identifier.endpage1120en_US
dc.identifier.issn0364-3190
dc.identifier.issn1573-6903
dc.identifier.issue6en_US
dc.identifier.pmid25859982en_US
dc.identifier.scopus2-s2.0-84931259963en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1111en_US
dc.identifier.urihttps://doi.org/10.1007/s11064-015-1571-8
dc.identifier.urihttps://hdl.handle.net/11616/96823
dc.identifier.volume40en_US
dc.identifier.wosWOS:000356095700003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofNeurochemical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEAEen_US
dc.subjectHesperidinen_US
dc.subjectC57BL/J6en_US
dc.subjectOxidative damageen_US
dc.subjectImmunological damageen_US
dc.titleHesperidin, a Citrus Flavonoid, Has the Ameliorative Effects Against Experimental Autoimmune Encephalomyelitis (EAE) in a C57BL/J6 Mouse Modelen_US
dc.typeArticleen_US

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