Long-Term Effects of Neonatal LPS and Caspase -1 İnhibitor Administration on Gonadotropin Levels and Testicular Histology in Rats

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dc.contributor.authorUcar, Cihat
dc.contributor.authorYıldız, Sedat
dc.contributor.authorYıldız, Azibe
dc.contributor.authorVardı, Nigar
dc.date.accessioned2024-08-04T19:53:15Z
dc.date.available2024-08-04T19:53:15Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Endotoxins (lipopolysaccharides, LPS) negatively affect reproduction by decreasing gonadotropin levels in the acute period. The aim of this study is to investigate the long-term effects of re-injection of endotoxin in adulthood on gonadotropin release and testicular tissue in male rats injected with endotoxin with IL-1 beta inhibitor (Q-Vd-OPh; caspase-1 inhibitor, Cİ) in the neonatal period.Material and Methods: On postnatal day 7, male rat pups were injected once with either Salin, LPS (50µg/kg), LPS (50µg/kg)+CI (1mg/kg). On postnatal 10 months, these rats were either injected with saline or LPS (50 µg/kg). 10 days after these injections, serum samples and testicular tissues were taken and the experiment was terminated.Results: Respectively, control, Salin+LPS, LPS+Salin; LPS+LPS; LPS(CI)+Salin and LPS(CI)+LPS groups were 18.8±1.6; 11.3±1.2; 23.4±2.0; 22.2±1.2 ve 23.6±1.4 ng/ml for serum LH concentrations (p<0,05); while 33.4±2.5; 29.6±1.4; 32.1,6±2.0 28.7 0.8 and 35.5±3.3 ng/ml for FSH concentrations (p>0,05). Seminiferous tubule damage was observed in LPS groups (p<0,05).Conclusion: This research demonstrates (1) neonatal LPS injections do not negatively affect gonadotropin release in the long term, (2) IL-1 ? plays a critical role in the programming of reproduction, especially in terms of testicular histology.en_US
dc.identifier.doi10.37990/medr.783590
dc.identifier.endpage28en_US
dc.identifier.issn2687-4555
dc.identifier.issue1en_US
dc.identifier.startpage22en_US
dc.identifier.trdizinid1125119en_US
dc.identifier.urihttps://doi.org/10.37990/medr.783590
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1125119
dc.identifier.urihttps://hdl.handle.net/11616/89613
dc.identifier.volume3en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMedical records-international medical journal (Online)en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleLong-Term Effects of Neonatal LPS and Caspase -1 İnhibitor Administration on Gonadotropin Levels and Testicular Histology in Ratsen_US
dc.typeArticleen_US

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