An investigation of histopathological changes and bioaccumulation in tissues of rainbow trout (Oncorhynchus mykiss) after exposure to dodine

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dc.authoriderdogan, selim/0000-0002-9169-9771
dc.authoridaydemir, songul/0000-0002-7921-0662
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridOzgur, Mustafa Erkan/0000-0002-2966-9627
dc.authorwosiderdogan, selim/AAT-2487-2020
dc.authorwosidaydemir, songul/AAA-4291-2021
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidTaşlıdere, Aslı/ABI-8274-2020
dc.contributor.authorBuyuksoylu, Semih
dc.contributor.authorOzgur, Mustafa Erkan
dc.contributor.authorGul, Cemile Ceren
dc.contributor.authorTaslidere, Asli
dc.contributor.authorAydemir, Songul
dc.contributor.authorErdogan, Selim
dc.date.accessioned2024-08-04T20:47:11Z
dc.date.available2024-08-04T20:47:11Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe purpose of this research is to determine ecotoxicological effects of dodine (n-dodecylguanidini acetate) on aquatic environments. Though dodine is widely used as a fungicide in agriculture, but there is no much data about its ecotoxicology. In this regard, we investigated bioaccumulation levels and histological alterations on the tissues of muscle, liver and gills in Rainbow Trout (Oncorhynchus mykiss) against different doses (0.01, 0.1, 0.5 and 1mg/L) of Dodine exposure. The tissues of fish were extracted according to QUECHERS method and analyzed by mass spectrometer (LC-MS-MS). Neither of the applied dodine doses resulted in killing 50% of the total individuals in the experimental groups. However, 48hours after doses, behaviors such as instability, anomaly in swimming or sudden jumping movements were observed. Histological results of the study showed deteriorations of the radiological pattern of hepatocytes, sinusoidal dilatations, hemorrhages, edemas, mononuclear cell infiltrations, vascular congestions, hyperplasia and hypertrophy in liver, gill and muscle tissues. Accumulation of dodine in tissues correlated with increase of dose. The maximum level of active substance accumulation in tissues were measured 96hours after application of 1mg/L dodine dose -in order- in gills, muscles and liver. The accumulations were statistically significant (p<0.05) when compared with control group.en_US
dc.description.sponsorshipInonu University Science Research Project Unit [TYL/2017-640]en_US
dc.description.sponsorshipThis manuscript is produced from Master Thesis titled Determination of drug accumulation in the Liver, Muscle and Gill of trout exposed to Dodine and its effects on the histology of the Tissues studied by Semih Buyuksoylu on 03/07/2018. We would like to thank to Inonu University Science Research Project Unit who supported to this thesis project (Project Number: TYL/2017-640).en_US
dc.identifier.doi10.1080/01480545.2020.1730884
dc.identifier.endpage547en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue2en_US
dc.identifier.pmid32102573en_US
dc.identifier.scopus2-s2.0-85080052259en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage537en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2020.1730884
dc.identifier.urihttps://hdl.handle.net/11616/99200
dc.identifier.volume45en_US
dc.identifier.wosWOS:000517037600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDodineen_US
dc.subjectfungicideen_US
dc.subjectOncorhynchus mykissen_US
dc.subjectLC-MS-MSen_US
dc.subjectQUECHERSen_US
dc.titleAn investigation of histopathological changes and bioaccumulation in tissues of rainbow trout (Oncorhynchus mykiss) after exposure to dodineen_US
dc.typeArticleen_US

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