Decreased placental adrenomedullin may play role in preeclampsia
Yükleniyor...
Dosyalar
Tarih
2000
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Journal of Medical Sciences
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Öz: Adrenomedullin (AdM) is a novel peptide that elicits a long-lasting vasorelaxant activity. It is expressed in several tissues, including adrenal medulla, heart, lung, kidneys, and cultured vascular smooth muscle cells. Also in large amounts, it is present in amniotic fluid and cord blood. The aim of this study was to assess placental AdM secretion in preeclampsia. Placental tissues were collected from seven preeclamptic patients and ten healthy gravidas. Tissue concentration of rat AdM was measured by using reverse-phase high performance liquid chromatography (Cecil 1100). Mann Whitney U test was used for statistical significance. Significance was set at p<0.05. AdM concentrations were 144.1±3.20 pmol/ml and 178.7±4.4 pmol/ml in preeclamptics and healthy gravidas respectively. This difference was significant (p<0.05). These data suggest that placental synthesis of AdM in preeclampsia is reduced, and low production of AdM may be responsible for placental pathology in preeclampsia.
Abstract: Adrenomedullin (AdM) is a novel peptide that elicits a long-lasting vasorelaxant activity. It is expressed in several tissues, including adrenal medulla, heart, lung, kidneys, and cultured vascular smooth muscle cells. Also in large amounts, it is present in amniotic fluid and cord blood. The aim of this study was to assess placental AdM secretion in preeclampsia. Placental tissues were collected from seven preeclamptic patients and ten healthy gravidas. Tissue concentration of rat AdM was measured by using reverse-phase high performance liquid chromatography (Cecil 1100). Mann Whitney U test was used for statistical significance. Significance was set at p<0.05. AdM concentrations were 144.1±3.20 pmol/ml and 178.7±4.4 pmol/ml in preeclamptics and healthy gravidas respectively. This difference was significant (p<0.05). These data suggest that placental synthesis of AdM in preeclampsia is reduced, and low production of AdM may be responsible for placental pathology in preeclampsia.
Abstract: Adrenomedullin (AdM) is a novel peptide that elicits a long-lasting vasorelaxant activity. It is expressed in several tissues, including adrenal medulla, heart, lung, kidneys, and cultured vascular smooth muscle cells. Also in large amounts, it is present in amniotic fluid and cord blood. The aim of this study was to assess placental AdM secretion in preeclampsia. Placental tissues were collected from seven preeclamptic patients and ten healthy gravidas. Tissue concentration of rat AdM was measured by using reverse-phase high performance liquid chromatography (Cecil 1100). Mann Whitney U test was used for statistical significance. Significance was set at p<0.05. AdM concentrations were 144.1±3.20 pmol/ml and 178.7±4.4 pmol/ml in preeclamptics and healthy gravidas respectively. This difference was significant (p<0.05). These data suggest that placental synthesis of AdM in preeclampsia is reduced, and low production of AdM may be responsible for placental pathology in preeclampsia.
Açıklama
Yıl: 2000Cilt: 30Sayı: 3ISSN: 1300-0144 / 1303-6165Sayfa Aralığı: 281 - 283Metin Dili:İngilizce
Anahtar Kelimeler
Kaynak
Turkish Journal of Medical Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
30
Sayı
3
Künye
GÖKDENİZ R,YÜREKLİ M,MENEKŞE A,BAZOĞLU N (2000). Decreased placental adrenomedullin may play role in preeclampsia. Turkish Journal of Medical Sciences, 30(3), 281 - 283.
