Topically applied water extract of propolis to suppress corneal neovascularization in rabbits

Basit Öğe Kaydı
dc.authorid, osman/0000-0003-0911-8649
dc.authorwosid, osman/H-3027-2019
dc.contributor.authorHepsen, IF
dc.contributor.authorEr, H
dc.contributor.authorÇekiç, O
dc.date.accessioned2024-08-04T20:12:00Z
dc.date.available2024-08-04T20:12:00Z
dc.date.issued1999
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: Propolis, a natural honey bee hive product, has anti-inflammatory and antioxidative properties. We aimed to assess the possible contribution of topically applied propolis to the suppression of corneal neovascularization (CNV). Methods: The effect of a water extract of propolis (WEP) 1% drops (group 1) in comparison with dexamethasone 0.1% (group 2) and saline (group 3) on CNV was tested in rabbit corneas injured by silver nitrate cauterization. The extent of CNV was quantitated as the area of CNV and the percent area of CNV for each cornea of the three groups (12 right eyes per group) in the first week of the treatment. The mean percent CNV was used for statistical analysis. Results: The corneas treated with the topical WEP 1% had an almost equal percent CNV as compared with the corneas treated with topical dexamethasone 0.1% and had less percent CNV than the control eyes. The quantitative analysis in groups 1, 2 and 3 revealed that the mean percent CNV was 41.0 +/- 14.1, 39.4 +/- 11.0 and 56.9 +/- 18.4, respectively. The differences between both groups 1 and 3 as well as groups 2 and 3 were statistically significant (p = 0.02 and p = 0.01, respectively), whereas the difference between groups 1 and 2 was not significant (p = 0.86). Conclusions The topical application of a WEP 1% has an inhibitory effect on CNV in the rabbit's cornea. The inhibitory effect of propolis was shown to be comparable to that of topical dexamethasone 0.1%, a potent inhibitor of angiogenesis. We suggest that the effect of propolis may partially be due to its inhibitory effect on the activity of both cyclo-oxygenase and lipo-oxygenase.en_US
dc.identifier.doi10.1159/000055567
dc.identifier.endpage431en_US
dc.identifier.issn0030-3747
dc.identifier.issue6en_US
dc.identifier.pmid10474071en_US
dc.identifier.scopus2-s2.0-0032852536en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage426en_US
dc.identifier.urihttps://doi.org/10.1159/000055567
dc.identifier.urihttps://hdl.handle.net/11616/93158
dc.identifier.volume31en_US
dc.identifier.wosWOS:000082988400006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofOphthalmic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchemical cauterizationen_US
dc.subjectcorneal neovascularizationen_US
dc.subjectcyclo-oxygenaseen_US
dc.subjectlipo-oxygenaseen_US
dc.subjectpropolisen_US
dc.titleTopically applied water extract of propolis to suppress corneal neovascularization in rabbitsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu