Detecting the shape differences of the corpus callosum in behçet s disease by statistical shape analysis

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dc.authorid9712en_US
dc.authorid19524en_US
dc.contributor.authorÇolak, Cemil
dc.contributor.authorErcan, İlker
dc.contributor.authorDoğan, Metin
dc.contributor.authorÖzdemir, Senem Turan
dc.contributor.authorŞener, Serpil
dc.contributor.authorAlkan, Alpay
dc.date.accessioned2018-01-09T07:18:56Z
dc.date.available2018-01-09T07:18:56Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.descriptionThe Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biologyen_US
dc.description.abstractThe aim of this study was to assess the shape differences of the cor-pus callosum (CC) in patients with Behc¸et’s disease using statisticalshape analysis (SSA). Additionally, an attempt was made to investigatethe changes in CC size according to disease duration. Twenty-five adultswith clinically diagnosed Behc¸et’s disease and 25 age- and gender-matched controls were examined by high-resolution structural magneticresonance imaging. The data obtained from the coordinate of landmarkswere analyzed with Euclidean distance matrix analysis and a thin-platespline analysis. SSA and growth curve models were performed to investi-gate group differences and to fit the curves. A significant difference wasdetermined between CC shape of Behc¸et patients and controls (P ¼0.006). Based on the analysis, a decrease occurred in the CC size of theBehc¸et patients as the duration of disease increased. Maximum deforma-tions were determined in the landmarks of interior notch of the splenium,inferior tip of the splenium, posterior-most point of the CC, and topmostpoint of the CC. Similarly, the landmark of anterior-most point of the CCwas identified as having the minimum deformation. Behc¸et patients hadsignificantly different CC shapes from control subjects. The results sug-gest that SSA is a promising tool for distinguishing Behc¸et patients fromnormal subjects, and that it can give useful information to assist clini-cians. Additionally, SSA might be applied to detect shape differences inanatomical structures that are affected by a broad range of neurologicaldiseases. Anat Rec, 294:870–874, 2011.VVC2011 Wiley-Liss, Inc.en_US
dc.identifier.citationColak, C., Ercan, I., Dogan, M., Ozdemir, Senem T., Sener, S., Alkan, A. (2011). Detecting the shape differences of the corpus callosum in behçet s disease by statistical shape analysis. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology.en_US
dc.identifier.doi10.1002/ar.21373en_US
dc.identifier.endpage0en_US
dc.identifier.issue0en_US
dc.identifier.startpage0en_US
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1002/ar.21373/epdf
dc.identifier.urihttps://hdl.handle.net/11616/7962
dc.identifier.volume0en_US
dc.language.isoenen_US
dc.publisherThe Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biologyen_US
dc.relation.ispartofThe Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBehcet diaesesen_US
dc.subjectCorpus callosumen_US
dc.subjectGeometricmorphometricsen_US
dc.subjectGrowth curve modelsen_US
dc.subjectStatisticalshape analysisen_US
dc.titleDetecting the shape differences of the corpus callosum in behçet s disease by statistical shape analysisen_US
dc.typeArticleen_US

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