Subacute toxicity of uranyl acetate in Swiss-Albino mice

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dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authoridOzmen, Murat/0000-0003-4378-0839
dc.authorwosidOZMEN, MURAT/A-4874-2009
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.contributor.authorOzmen, M
dc.contributor.authorYurekli, M
dc.date.accessioned2024-08-04T20:11:59Z
dc.date.available2024-08-04T20:11:59Z
dc.date.issued1998
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSubacute effects of uranyl acetate were investigated in laboratory mice (Mus musculus, Swiss-Albino). Uranyl acetate was administrated to mice during a period of 5 days with dietary consumption ad libitum. Effects of uranyl acetate on food and water consumption, body weight changes; plasma urea nitrogen (:BUN), creatinine concentrations and activities of alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were assayed by time-course experiment. Glutathione S-transferase (GST) and catalase (CAT) activities were also determined in liver tissues on day 5. Distribution of radioactivity in liver, kidney and brain was detected by scintillation spectrometry. The results indicated that uranyl acetate was accumulated in examined tissues, with highest accumulation being in brain. Some of the biochemical biomarkers (BUN, creatinine, ALP) were significantly increased (P < 0.05) in the exposure group compared to control animals. Also, BUN and/or creatinine levels and/or ALT and AST activities significantly increased (P < 0.01 or P < 0.05) with UA exposure on day 3 and/or day 5 compared with results of day 1. (C) 1998 Elsevier Science B.V. All rights reserved.en_US
dc.identifier.doi10.1016/S1382-6689(98)00025-8
dc.identifier.endpage115en_US
dc.identifier.issn1382-6689
dc.identifier.issn1872-7077
dc.identifier.issue2en_US
dc.identifier.pmid21781887en_US
dc.identifier.scopus2-s2.0-0032416849en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage111en_US
dc.identifier.urihttps://doi.org/10.1016/S1382-6689(98)00025-8
dc.identifier.urihttps://hdl.handle.net/11616/93135
dc.identifier.volume6en_US
dc.identifier.wosWOS:000076605500005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEnvironmental Toxicology and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecturanyl acetateen_US
dc.subjecttoxicityen_US
dc.subjectbiomarkeren_US
dc.subjectmiceen_US
dc.titleSubacute toxicity of uranyl acetate in Swiss-Albino miceen_US
dc.typeArticleen_US

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