Intravitreal cortisone injection for refractory diffuse diabetic macular edema

Basit Öğe Kaydı
dc.contributor.authorEr, H
dc.contributor.authorYilmaz, H
dc.date.accessioned2024-08-04T20:15:05Z
dc.date.available2024-08-04T20:15:05Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: The purpose of this study was to evaluate the safety and efficacy of intravitreal triamcinolone acetonide injection in patients with diffuse diabetic macular edema. We also compared the effect of intravitreal triamcinolone with macular grid laser photocoagulation in macular edema. Patients and Methods: Thirty patients with diabetic diffuse macular edema unresponsive to grid laser photocoagulation for at least 4 months received 0.1 ml ( 4 mg/ml) intravitreal triamcinolone acetonide ( Kenakort-A) injection as treatment. This study group was compared with a control group of 30 patients ( 30 eyes) who had undergone grid laser macular coagulation. Mean follow-up time was 17 months ( range 14 - 24 months) in the study group and 19 months ( range 16 - 24 months) in the control group. Results: In the study group, mean improvement in visual acuity measured 3.8, 3.4, 0.9 and 0.2 Snellen lines at the follow-up intervals of 1, 3, 6 and 12 months, respectively. Improvement in visual acuity was statistically significant only at 1 month ( p = 0.002) and 3 months ( p = 0.003) after injection. Visual acuity was significantly ( p < 0.05) better in the study group than the control group at 1 and 3 months. Overall, 6 of 30 eyes ( 20%) required a second injection and 3 eyes ( 10%) a third due to regression in visual acuity. Towards the end of the follow-up period, the visual acuity decreased to almost baseline levels. Elevation of intraocular pressure was found in 4 patients and controlled with topical antiglaucomatosis treatment. Sterile endophthalmitis was detected in only one eye. No eye exhibited cataract progression during the follow-up period. Conclusion: Intravitreal injection of triamcinolone may be beneficial for temporarily increasing visual acuity in patients with diabetic diffuse macular edema who are unresponsive even to grid laser photocoagulation. But the regression of visual acuity looks inevitable in the long term after injection. Therefore, repeated injections with/without increasing doses might be required for the stabilization of visual acuity. Copyright (c) 2005 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000088385
dc.identifier.endpage400en_US
dc.identifier.issn0030-3755
dc.identifier.issn1423-0267
dc.identifier.issue6en_US
dc.identifier.pmid16286802en_US
dc.identifier.scopus2-s2.0-27744499327en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage394en_US
dc.identifier.urihttps://doi.org/10.1159/000088385
dc.identifier.urihttps://hdl.handle.net/11616/94160
dc.identifier.volume219en_US
dc.identifier.wosWOS:000233364800014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofOphthalmologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdiffuse macular edemaen_US
dc.subjectdiabetesen_US
dc.subjectintravitreal cortisoneen_US
dc.subjectlaser coagulationen_US
dc.titleIntravitreal cortisone injection for refractory diffuse diabetic macular edemaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu