Effect of clozapine on locomotor activity and anxiety-related behavior in the neonatal mice administered MK-801

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dc.authoridSefil, Fatih/0000-0001-5534-7448
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authorwosidSefil, Fatih/C-3094-2011
dc.authorwosidAkillioglu, Kübra/H-2038-2014
dc.authorwosidSefil, Fatih/AAR-6907-2020
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.contributor.authorPinar, Neslihan
dc.contributor.authorAkillioglu, Kubra
dc.contributor.authorSefil, Fatih
dc.contributor.authorAlp, Harun
dc.contributor.authorSagir, Mustafa
dc.contributor.authorAcet, Ahmet
dc.date.accessioned2024-08-04T20:41:50Z
dc.date.available2024-08-04T20:41:50Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAtypical antipsychotics have been used to treat fear and anxiety disturbance that are highly common in schizophrenic patients. It is suggested that disruptions of N-methyl-d-aspartate (NMDA)-mediated transmission of glutamate may underlie the pathophysiology of schizophrenia. The present study was conducted to analyze the effectiveness of clozapine on the anxiety-related behavior and locomotor function of the adult brain, which had previously undergone NMDA receptor blockade during a developmental period. In order to block the NMDA receptor, male mice were administered 0.25 mg/kg of MK-801 on days 7 to 10 postnatal. In adulthood, they were administered intraperitoneally 0.5 mg/kg of clozapine and tested with open-field and elevated plus maze test, to assess their emotional behavior and locomotor activity. In the group receiving MK-801 in the early developmental period the elevated plus maze test revealed a reduction in the anxiety-related behavior (p<0.05), while the open-field test indicated a decrease in locomotor activity (p<0.01). Despite these reductions, clozapine could not reverse the NMDA receptor blockade. Also, as an atypical antipsychotic agent, clozapine could not reverse impairment in the locomotor activity and anxiety-related behavior, induced by administration of the MK-801 in neonatal period.en_US
dc.description.sponsorshipScientific Research Office of Inonu University (I.U BAP) [2011/83]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research Office of Inonu University (I.U BAP) (Project no: 2011/83).en_US
dc.identifier.endpage79en_US
dc.identifier.issn1512-8601
dc.identifier.issn1840-4812
dc.identifier.issue3en_US
dc.identifier.pmid26295298en_US
dc.identifier.scopus2-s2.0-84975113452en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage74en_US
dc.identifier.urihttps://hdl.handle.net/11616/97376
dc.identifier.volume15en_US
dc.identifier.wosWOS:000361745100011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevoen_US
dc.relation.ispartofBosnian Journal of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMK-801en_US
dc.subjectclozapineen_US
dc.subjectopen field testen_US
dc.subjectelevated plus maze testen_US
dc.subjectneonatal miceen_US
dc.titleEffect of clozapine on locomotor activity and anxiety-related behavior in the neonatal mice administered MK-801en_US
dc.typeArticleen_US

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