Does alfa lipoic acid prevent liver from methotrexate induced oxidative injury in rats?

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dc.authoridGül, Semir/0000-0002-4668-9603
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridPOLAT, Cemal/0000-0002-1587-3934
dc.authoridsabuncuoglu, mehmet zafer/0000-0002-5549-4023;
dc.authorwosidGül, Semir/ABI-8244-2020
dc.authorwosidBasturk, Ahmet/V-9914-2017
dc.authorwosidtahir, oruc mehmet/AAR-5753-2020
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidPOLAT, Cemal/ADL-8092-2022
dc.authorwosidsabuncuoglu, mehmet zafer/KIG-1933-2024
dc.authorwosidPolat, Cemal/AAX-9226-2020
dc.contributor.authorCakiri, Tugrul
dc.contributor.authorBasturk, Ahmet
dc.contributor.authorPolat, Cemal
dc.contributor.authorAslaner, Arif
dc.contributor.authorDurgut, Himmet
dc.contributor.authorSehirli, Ahmet Ozer
dc.contributor.authorGul, Mehmet
dc.date.accessioned2024-08-04T20:40:11Z
dc.date.available2024-08-04T20:40:11Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPURPOSE: To determine the antioxidant and anti-inflammatory effects of alfa lipoic acid (ALA) on the liver injury induced by methotrexate (MTX) in rats. METHODS: Thirty two rats were randomly assigned into four equal groups; control, ALA, MTX and MTX with ALA groups. Liver injury was performed with a single dose of MTX (20 mg/kg) to groups 3 and 4. The ALA was administered intraperitonealy for five days in groups 2 and 4. The other rats received saline injection. At the sixth day the rats decapitated, blood and liver tissue samples were removed for TNF-alpha, IL-1 beta, malondialdehyde, glutathione, myeloperoxidase and sodium potassium-adenosine triphosphatase levels measurement and histological examination. RESULTS: MTX administration caused a significant decrease in tissue GSH, and tissue Na+, K+ ATPase activity and which was accompanied with significant increases in tissue MDA and MPO activity. Moreover the pro-inflammatory cytokines (TNF-alpha, IL-beta) were significantly increased in the MTX group. On the other hand, ALA treatment reversed all these biochemical indices as well as histopathological alterations induced by MTX. CONCLUSION: Alfa lipoic acid ameliorates methotrexate induced oxidative damage of liver in rats with its anti-inflammatory and antioxidant effects.en_US
dc.identifier.doi10.1590/S0102-865020150040000003
dc.identifier.endpage254en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue4en_US
dc.identifier.pmid25923257en_US
dc.identifier.scopus2-s2.0-84928747051en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage247en_US
dc.identifier.urihttps://doi.org/10.1590/S0102-865020150040000003
dc.identifier.urihttps://hdl.handle.net/11616/96770
dc.identifier.volume30en_US
dc.identifier.wosWOS:000353700300003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThioctic Aciden_US
dc.subjectMethotrexateen_US
dc.subjectLiveren_US
dc.subjectRatsen_US
dc.titleDoes alfa lipoic acid prevent liver from methotrexate induced oxidative injury in rats?en_US
dc.typeArticleen_US

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