Impact of periodontal status on the oral mucositis in patients receiving high-dose chemotherapy

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dc.authoridsabancı, arife/0000-0002-0956-1600
dc.authoridKirmizigul, Omer Alperen/0000-0001-5828-8949
dc.authorwosidsabancı, arife/ABG-9792-2020
dc.contributor.authorSabanci, Arife
dc.contributor.authorKarasu, Basak
dc.contributor.authorSabanci, Halil Ibrahim
dc.contributor.authorKuku, Irfan
dc.contributor.authorKirmizigul, Omer Alperen
dc.date.accessioned2024-08-04T20:53:03Z
dc.date.available2024-08-04T20:53:03Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives Oral mucositis (OM) is a frequent complication of cancer treatments. Oral mucositis and periodontal disease have a common inflammatory pattern. The purpose of this study was to evaluate the OM and its association with periodontal status in patients with hematologic malignancies who undergo high-dose chemotherapy. Materials and methods Fifty-five patients who received high-dose chemotherapy were included in the study. Full-mouth periodontal clinical measurements including plaque index (PI), gingival index (GI), clinical attachment level (CAL), and probing depth (PD) values were recorded before the condition chemotherapy regime. OM monitoring was initiated 1 day after the chemotherapy and maintained for 20 days. Results Twenty-two of patients (40%) were observed oral mucositis after high-dose chemotherapy. Patients with mucositis had significantly higher GI scores than those who did not have mucositis (p < 0.05). There was a significantly moderate positive correlation between the grade of mucositis and GI scores (p < 0.05). In patients with periodontitis, the incidence of grade 1-2 mucositis was significantly higher than in the healthy group (p < 0.05). In individuals with periodontitis and gingivitis, the healing duration of mucositis was significantly longer than the healthy group (p < 0.05). Conclusions The results of this study showed that the severity grades of oral mucositis may increase in patients with gingival inflammation. The results also suggest that periodontal diseases may have a significant impact on the duration of oral mucositis.en_US
dc.identifier.doi10.1007/s00784-022-04588-6
dc.identifier.endpage6346en_US
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.issue10en_US
dc.identifier.pmid35906338en_US
dc.identifier.scopus2-s2.0-85139530810en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage6341en_US
dc.identifier.urihttps://doi.org/10.1007/s00784-022-04588-6
dc.identifier.urihttps://hdl.handle.net/11616/100933
dc.identifier.volume26en_US
dc.identifier.wosWOS:000832824500002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofClinical Oral Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHigh-dose chemotherapyen_US
dc.subjectOral mucositisen_US
dc.subjectGingivitisen_US
dc.subjectPeriodontitisen_US
dc.titleImpact of periodontal status on the oral mucositis in patients receiving high-dose chemotherapyen_US
dc.typeArticleen_US

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