Protective Effects of Apocynin on Cisplatin-induced Hepatotoxicity in Rats

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dc.authoridYildiz, Azibe/0000-0001-5686-7867
dc.authoriderdogan, mehmet ali/0000-0002-1713-5695
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridTANBEK, Kevser/0000-0003-2099-2273
dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authoridCagin, Yasir Furkan/0000-0002-2538-857X
dc.authorwosidYildiz, Azibe/ABI-7998-2020
dc.authorwosiderdogan, mehmet ali/ABI-4675-2020
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidTANBEK, Kevser/ITR-9264-2023
dc.authorwosidTanbek, Kevser/ABI-1174-2020
dc.authorwosidCagin, Yasir Furkan/ABI-2709-2020
dc.contributor.authorCagin, Yasir Furkan
dc.contributor.authorErdogan, Mehmet Ali
dc.contributor.authorSahin, Nurhan
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorAtayan, Yahya
dc.contributor.authorPolat, Alaadin
dc.contributor.authorVardi, Nigar
dc.date.accessioned2024-08-04T20:41:17Z
dc.date.available2024-08-04T20:41:17Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Aims. Despite it being a highly potent antineoplastic drug, cisplatin has important toxic adverse effects limiting its use such as nephrotoxicity, neurotoxicity and ototoxicity. It is thought that cisplatin-induced hepatotoxicity is caused by oxidative stress resulting from increased reactive oxygen species (ROS). Apocynin (APO) exerts its antioxidant effect by reducing ROS production via inhibition of NADPH oxidase. The present study intended to demonstrate effects of cisplatin on hepatic pro-oxidant/antioxidant systems and to investigate protective effects of APO against cisplatin-induced hepatotoxicity. Methods. Rats were randomly assigned into four groups (n = 8 each): a) control group; b) single dose of cisplatin (5 mg/kg); c) APO group (20 mg/kg on three consecutive days; i.p.); and d) APO plus cisplatin group. Liver tissue was assessed in all groups by biochemical and histopathological means. Also, serum alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase levels were studied in all groups. Results. When cisplatin group was compared to controls, it was seen that lipid peroxidation product, total oxidant status and ALT levels were markedly increased, whereas superoxide clismutase and glutathione peroxidase levels were overtly decreased. APO therapy markedly prevented cisplatin-induced harmful changes in liver. Our histopathological findings such as central vein dilatation, perivenuler and periportal sinusoidal dilatation, parenchymal inflammation, vacuolar changes in hepatocytes, biliary duct proliferation and caspase-3 positive hepatocytes were in accordance with the biochemical changes. Conclusion. In light of these results, it is our thought that APO has a protective role against cisplatin-induced hepatotoxicity at both biochemical and histopathological levels. (C) 2015 IMSS. Published by Elsevier Inc.en_US
dc.identifier.doi10.1016/j.arcmed.2015.08.005
dc.identifier.endpage526en_US
dc.identifier.issn0188-4409
dc.identifier.issn1873-5487
dc.identifier.issue7en_US
dc.identifier.pmid26319609en_US
dc.identifier.scopus2-s2.0-84946063461en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage517en_US
dc.identifier.urihttps://doi.org/10.1016/j.arcmed.2015.08.005
dc.identifier.urihttps://hdl.handle.net/11616/97035
dc.identifier.volume46en_US
dc.identifier.wosWOS:000366145800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofArchives of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatinen_US
dc.subjectApocyninen_US
dc.subjectHepatotoxicityen_US
dc.subjectOxidative stressen_US
dc.titleProtective Effects of Apocynin on Cisplatin-induced Hepatotoxicity in Ratsen_US
dc.typeArticleen_US

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