The Effect of Beta Glucan on Cisplatin Ototoxicity

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dc.authoridBayindir, Tuba/0000-0003-4150-5016
dc.authoridTAN, MEHMET/0000-0001-8557-0886
dc.authoridtoplu, yuksel/0000-0002-5444-557X
dc.authorwosidBayindir, Tuba/ABG-9517-2020
dc.authorwosidTAN, MEHMET/ABI-7574-2020
dc.authorwosidToplu, Yuksel/AAA-3133-2021
dc.authorwosidKALCIOGLU, Mahmut Tayyar/I-5884-2013
dc.authorwosidKalcioglu, M. Tayyar/JAC-1515-2023
dc.contributor.authorBayindir, Tuba
dc.contributor.authorIraz, Mustafa
dc.contributor.authorKelles, Mehmet
dc.contributor.authorKaya, Serdar
dc.contributor.authorTan, Mehmet
dc.contributor.authorFiliz, Aliye
dc.contributor.authorToplu, Yuksel
dc.date.accessioned2024-08-04T20:39:41Z
dc.date.available2024-08-04T20:39:41Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study was undertaken to investigate the effect of betaglucan in ameliorating cisplatin ototoxicity. Rats were divided into four groups: cisplatin (C), cisplatin plus beta glucan (CB), beta glucan (B), and control (K). Distortion product otoacoustic emissions were elicited in 0th, 1st, and 5th days. For the group C differences were observed at 8,003 and 9,515 Hz between 0th and 5th days' measurements. In the group CB there were differences at frequencies of 3,996, 4,757, 5,660, and 6,726 Hz between 0th and 5th days' measurements. For the group B there were significant recovery in some frequencies. The observation of significant deterioration in terms of hearing in the group treated with cisplatin plus betaglucan may be suggested that depended on the increase of permeability and tissue conductance into the inner ear which may be caused by betaglucan. Further long-term follow-up studies by using different doses may clarify this matter.en_US
dc.identifier.doi10.1007/s12070-013-0623-0
dc.identifier.endpage134en_US
dc.identifier.issn2231-3796
dc.identifier.issn0973-7707
dc.identifier.issue2en_US
dc.identifier.pmid24822149en_US
dc.identifier.scopus2-s2.0-84900018733en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage131en_US
dc.identifier.urihttps://doi.org/10.1007/s12070-013-0623-0
dc.identifier.urihttps://hdl.handle.net/11616/96439
dc.identifier.volume66en_US
dc.identifier.wosWOS:000422257700002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal of Otolaryngology and Head & Neck Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOtotoxicityen_US
dc.subjectCisplatinen_US
dc.subjectBetaglucanen_US
dc.subjectOtoacoustic emissionsen_US
dc.titleThe Effect of Beta Glucan on Cisplatin Ototoxicityen_US
dc.typeArticleen_US

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