Injection Therapy in Patients with Lateral Epicondylalgia: Hyaluronic Acid or Dextrose Prolotherapy? A Single-Blind, Randomized Clinical Trial

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dc.authoridBAZANCİR APAYDIN, ZİLAN/0000-0001-6834-8343
dc.authoridAPAYDIN, HAKAN/0000-0001-7219-1457
dc.authorwosidBAZANCİR APAYDIN, ZİLAN/AFN-1331-2022
dc.authorwosidAltay, Zuhal/AAC-4361-2021
dc.contributor.authorApaydin, Hakan
dc.contributor.authorBazancir, Zilan
dc.contributor.authorAltay, Zuhal
dc.date.accessioned2024-08-04T20:49:08Z
dc.date.available2024-08-04T20:49:08Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective:To compare the effects of hyaluronic acid (HA) and dextrose prolotherapy (DPT) injections in patients with chronic lateral epicondylalgia (LE). Materials and Methods:Thirty-two patients with at least 6 months of signs and symptoms of LE were randomly allocated into two groups: an HA group (n = 16) and a DPT group (n = 16). HA injection was performed as a single dose of 30 mg/2 mL 1500 kDa high-molecular-weight preparation (baseline). DPT injection was administered with 15% dextrose solution in three doses (baseline, third week, and sixth week). Severity of pain using the visual analog scale score, grip strength with a hand dynamometer, and physical function as determined by the Quick-Disabilities of the Arm, Shoulder, and Hand (Q-DASH) score were determined. Results:DPT was favored over HA for improvements from 0 to 12 weeks for pain with activity (4.81 +/- 1.2 vs. 3.18 +/- 2.3;p = 0.04), pain at night (5.1 +/- 1.9 vs. 4.1 +/- 2.2;p = 0.03), and pain at rest (3.8 +/- 2.09 vs. 2.7 +/- 1.7;p = 0.04). Q-DASH scores improved significantly more from 0 to 12 weeks in the DPT group (43.5 +/- 17.6 vs. 28.4 +/- 13.4;p = 0.04). No between-group improvement was observed for grip pain (7.3 +/- 6.4 vs. 4.8 +/- 3.2;p = 0.38). Conclusions:HA and DPT injections were both effective in reducing pain and increasing grip strength and function in patients with chronic LE. DPT injection was more effective in the short term than HA injection, in terms of pain relief and functional outcome. The study was registered atClinicalTrials.govunder the identifier number NCT04395417.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Unit [2018/1139]en_US
dc.description.sponsorshipThe authors would like to thank the Inonu University Scientific Research Projects Unit for HA support (Project No: 2018/1139).en_US
dc.identifier.doi10.1089/acm.2020.0188
dc.identifier.endpage1175en_US
dc.identifier.issn1075-5535
dc.identifier.issn1557-7708
dc.identifier.issue12en_US
dc.identifier.pmid32931308en_US
dc.identifier.scopus2-s2.0-85097904778en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1169en_US
dc.identifier.urihttps://doi.org/10.1089/acm.2020.0188
dc.identifier.urihttps://hdl.handle.net/11616/99678
dc.identifier.volume26en_US
dc.identifier.wosWOS:000570942100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofJournal of Alternative and Complementary Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthyaluronic aciden_US
dc.subjectlateral epicondylitisen_US
dc.subjectdextrose prolotherapyen_US
dc.subjecttennis elbowen_US
dc.titleInjection Therapy in Patients with Lateral Epicondylalgia: Hyaluronic Acid or Dextrose Prolotherapy? A Single-Blind, Randomized Clinical Trialen_US
dc.typeArticleen_US

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