Potential linkages between circadian rhythm and membrane lipids: timekeeper and bilayer

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dc.authoridGuldur, Tayfun/0000-0002-1623-2880
dc.contributor.authorGuldur, Tayfun
dc.date.accessioned2024-08-04T20:52:07Z
dc.date.available2024-08-04T20:52:07Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMembrane lipids play significant roles in cellular functions, including those controlled by circadian machinery (e.g., membrane transport). Membranes have been overlooked during the investigation of circadian mechanisms. The findings of previous studies suggest that membrane action potentials and phospholipid composition exhibit daily oscillations, which involve changes in fatty acid saturation and chain length, and are subjected to fatty chain remodeling. Thus, it is possible that membranes are affected by oscillatory output rhythms from cellular autonomous clocks. The regulation of lipid chain length and degree of unsaturation, along with resulting changes in membrane lipid polymorphic properties, may serve as the basis of an important mechanism that mediates the circadian regulation of various membrane-associated processes. However, direct evidence indicating that membrane lipid oscillations are part of the circadian machinery has yet to be reported. This review updates the current understanding of potential connections between the membrane bilayer and the circadian clock, with important implications for circadian rhythm disorders and related chronic diseases, such as obesity, diabetes, and cardiovascular disease.en_US
dc.identifier.doi10.1080/09291016.2022.2096756
dc.identifier.endpage130en_US
dc.identifier.issn0929-1016
dc.identifier.issn1744-4179
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85133434375en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage117en_US
dc.identifier.urihttps://doi.org/10.1080/09291016.2022.2096756
dc.identifier.urihttps://hdl.handle.net/11616/100767
dc.identifier.volume54en_US
dc.identifier.wosWOS:000822048600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiological Rhythm Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCircadian rhythmen_US
dc.subjectlipid bilayeren_US
dc.subjectmembrane lipiden_US
dc.subjectphospholipiden_US
dc.titlePotential linkages between circadian rhythm and membrane lipids: timekeeper and bilayeren_US
dc.typeReview Articleen_US

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