New silver, rhodium and iridium complexes with anthracene-functionalized N-heterocyclic carbene ligands: Crystal structures, cytotoxicity and fluorescence studies

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dc.authoridÖzdemir, Namık/0000-0003-3371-9874
dc.authoridŞAHİN, Zeynel/0000-0002-7719-7652
dc.authorwosidÖzdemir, Namık/J-6434-2015
dc.authorwosidŞAHİN, Zeynel/AAN-9585-2021
dc.contributor.authorBekci, Hatice
dc.contributor.authorOzdemir, Namuk
dc.contributor.authorSahin, Zeynel
dc.contributor.authorMumcu, Akun
dc.contributor.authorDayan, Serkan
dc.contributor.authorKaratas, Mert Olgun
dc.date.accessioned2024-08-04T20:55:57Z
dc.date.available2024-08-04T20:55:57Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn the present study, we have synthesized anthracene-functionalized metal complexes to investigate their cytotoxicity and photophysical properties. In this context, firstly, an Ag - NHC (NHC = N -heterocyclic carbene) complex ( 2a ) has been synthesized by the interaction of Ag 2 O and N -(2-methylbenzyl)- N -((anthracen-9-yl) methyl)benzimidazolium chloride ( 1a ). Corresponding Rh - ( 3a ) and Ir - NHC ( 4a ) complexes have also been synthesized by the transmetalation reaction between 2a and corresponding metal compounds. Additionally, for comparison purposes, an ether-functionalized Ag - NHC complex ( 2b ) with N -(methoxyethyl)- N -((anthracene-9- yl)methyl)benzimidazole-2-ylidene ligand, and [AgL 2 ]NO 3 type complex ( 2c ) with a N -coordinated N - ((anthracen-9-yl)methyl)benzimidazole ligand have been synthesized. All complexes have been characterized by the combination of NMR and mass spectroscopic techniques, and elemental analyses. Moreover, solid state structures of 2a , 2b and 4a have been determined by the single crystal X-ray diffraction analysis. Cytotoxic potentials of all compounds have been tested against human lung adenocarcinoma alveolar basal epithelial cell line (A549) using the MTT assay, and all complexes performed strong anti-proliferative activity. Stability studies have disclosed that only 1a and 2c are able to retain their structure in the culture medium (DMEM) that biological assays were carried out. Photophysical measurements revealed that all compounds have similar emission bands because of the conjugation of anthracene group. Finally, 1a and 2c have been visualized by fluorescence confocal microscopy to investigate cellular uptake and subcellular distribution of the complexes, and the findings indicated that both compounds dispersed along the cell membranes nuclear regions.en_US
dc.identifier.doi10.1016/j.poly.2024.117011
dc.identifier.issn0277-5387
dc.identifier.issn1873-3719
dc.identifier.scopus2-s2.0-85191655159en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.poly.2024.117011
dc.identifier.urihttps://hdl.handle.net/11616/101953
dc.identifier.volume257en_US
dc.identifier.wosWOS:001236259100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPolyhedronen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzimidazoleen_US
dc.subjectAnthraceneen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectSilveren_US
dc.subjectRhodiumen_US
dc.subjectIridiumen_US
dc.subjectFluorescenceen_US
dc.subjectCytotoxicityen_US
dc.titleNew silver, rhodium and iridium complexes with anthracene-functionalized N-heterocyclic carbene ligands: Crystal structures, cytotoxicity and fluorescence studiesen_US
dc.typeArticleen_US

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