The effects of synthetic organoselenium compounds on nitric oxide in DMBA - Induced rat liver

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dc.authorscopusid23471088100
dc.authorscopusid8842895700
dc.authorscopusid7005334931
dc.authorscopusid7005138869
dc.authorscopusid7004914053
dc.contributor.authorTalas Z.S.
dc.contributor.authorBayraktar N.
dc.contributor.authorOzdemir I.
dc.contributor.authorGok Y.
dc.contributor.authorYilmaz I.
dc.date.accessioned2024-08-04T19:59:21Z
dc.date.available2024-08-04T19:59:21Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDMBA (7,12-dimethylbenz[a]anthracene) is known to generate DNA-reactive species during their metabolism, which may enhance oxidative stress in cells. Since selenium is known as a non-enzymic antioxidant, health problems induced by many environmental pollutants, have stimulated the evaluation of relative antioxidant potential of selenium and synthetic organoselenium compounds. Therefore, we aimed to evaluate chemopreventive potential of synthetic organoselenium compounds by monitoring level of liver nitric oxide. In this study, adult female Wistar rats were treated with DMBA and the novel organoselenium compounds (Se I) and (Se II) in the determined doses. DMBA-induced in rats, the effects of organoselenium compounds on nitric oxide levels in rat liver was studied. In this study, it has been observed a statistically significant increase in (Nitric Oxide) levels for the liver of rat exposed to DMBA (p<0.05). However with administration of Se I and Se II there was a statistically significant decrease in NO levels (p<0.05). The ability of the organoselenium compounds to prevent oxidative damage induced by DMBA in rat livers was rationalized. Protection against nitric oxide measured in Se I and Se II treated groups were provided by synthesized organoselenium compounds. Se I and Se II both provided chemoprevention against DMBA-induced oxidative stress in rat liver. © Triveni Enterprises.en_US
dc.identifier.endpage593en_US
dc.identifier.issn0254-8704
dc.identifier.issue4en_US
dc.identifier.pmid20120501en_US
dc.identifier.scopus2-s2.0-67749137359en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage591en_US
dc.identifier.urihttps://hdl.handle.net/11616/90550
dc.identifier.volume30en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTriveni Enterprisesen_US
dc.relation.ispartofJournal of Environmental Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDMBAen_US
dc.subjectLiveren_US
dc.subjectNitric oxideen_US
dc.subjectRat and synthetic organoselenium compoundsen_US
dc.titleThe effects of synthetic organoselenium compounds on nitric oxide in DMBA - Induced rat liveren_US
dc.typeArticleen_US

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