A Guidance Manual for the Toxicity Assessment of Traditional Herbal Medicines

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dc.authoridYESILADA, ERDEM/0000-0002-1348-6033;
dc.authorwosidAydin, Ahmet/AAA-5688-2021
dc.authorwosidYESILADA, ERDEM/E-4743-2011
dc.authorwosidAydın, Ahmet/L-5069-2016
dc.contributor.authorAydin, Ahmet
dc.contributor.authorAktay, Goknur
dc.contributor.authorYesilada, Erdem
dc.date.accessioned2024-08-04T20:43:10Z
dc.date.available2024-08-04T20:43:10Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHerbal remedies have been used for thousands of years in worldwide traditional medicines for their potential health benefits. Although they are generally presumed safe unless a significant risk has been identified in humans, increasing number of case reports notify acute or chronic intoxications resulting from their use. This study aims to produce a scientific guide for the evaluation of traditional herbal medicines (THMs) in terms of their toxicity risks based on the published regulatory documents. For this purpose recommended in vitro and in vivo toxicity tests on medicinal products for human use issued by the international regulatory bodies are overviewed and they are then adopted to be used for the toxicity assessment of THMs. Accordingly, based on compilation of these issued regulations, the following tests are recommended for the toxicity assessment of THMs; in vitro cytotoxicity, genotoxicity, acute and repeated dose toxicity, carcinogenicity, reproductive and developmental toxicity, local tolerance tests, toxicokinetic studies, and additional toxicity tests including safety pharmacology, immunotoxicity and antigenicity, endocrine system toxicity, gastro-intestinal toxicity, renal and hepatotoxicity, and drug interaction studies. This study describes and discusses the applicability of these tests for the risk assessment in THMs.en_US
dc.identifier.endpage1773en_US
dc.identifier.issn1934-578X
dc.identifier.issn1555-9475
dc.identifier.issue11en_US
dc.identifier.pmid30475523en_US
dc.identifier.scopus2-s2.0-85019105005en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1763en_US
dc.identifier.urihttps://hdl.handle.net/11616/97811
dc.identifier.volume11en_US
dc.identifier.wosWOS:000388251200031en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNatural Products Incen_US
dc.relation.ispartofNatural Product Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectToxicity assessmenten_US
dc.subjectTraditional herbal medicinesen_US
dc.subjectHerbal remedyen_US
dc.subjectHerbal medicinal productsen_US
dc.titleA Guidance Manual for the Toxicity Assessment of Traditional Herbal Medicinesen_US
dc.typeReview Articleen_US

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